Genomic and biochemical insights into the specificity of ETS transcription factors
PC Hollenhorst, LP McIntosh… - Annual review of …, 2011 - annualreviews.org
ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors.
These proteins direct gene expression in diverse normal and disease states by binding to …
These proteins direct gene expression in diverse normal and disease states by binding to …
The ets transcription factor Fli-1 in development, cancer and disease
Y Li, H Luo, T Liu, E Zacksenhaus, Y Ben-David - Oncogene, 2015 - nature.com
Friend leukemia virus-induced erythroleukemia-1 (Fli-1), an E26 transformation specific
(ETS) transcription factor, was isolated a quarter century ago through a retrovirus …
(ETS) transcription factor, was isolated a quarter century ago through a retrovirus …
In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
Improving effector activity of antigen-specific T cells is a major goal in cancer
immunotherapy. Despite the identification of several effector T cell (T EFF)-driving …
immunotherapy. Despite the identification of several effector T cell (T EFF)-driving …
Deregulation of DUX4 and ERG in acute lymphoblastic leukemia
Chromosomal rearrangements deregulating hematopoietic transcription factors are common
in acute lymphoblastic leukemia (ALL). Here we show that deregulation of the homeobox …
in acute lymphoblastic leukemia (ALL). Here we show that deregulation of the homeobox …
BET bromodomain inhibition suppresses the function of hematopoietic transcription factors in acute myeloid leukemia
The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in
leukemia, yet its regulatory function in this disease is not well understood. Here, we show …
leukemia, yet its regulatory function in this disease is not well understood. Here, we show …
Interrogation of human hematopoiesis at single-cell and single-variant resolution
Widespread linkage disequilibrium and incomplete annotation of cell-to-cell state variation
represent substantial challenges to elucidating mechanisms of trait-associated genetic …
represent substantial challenges to elucidating mechanisms of trait-associated genetic …
ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation
The EWS-FLI1 fusion oncoprotein deregulates transcription to initiate the paediatric cancer
Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the …
Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the …
Single-cell analyses reveal early thymic progenitors and pre-B cells in zebrafish
SA Rubin, CS Baron, C Pessoa Rodrigues… - Journal of Experimental …, 2022 - rupress.org
The zebrafish has proven to be a valuable model organism for studying hematopoiesis, but
relatively little is known about zebrafish immune cell development and functional diversity …
relatively little is known about zebrafish immune cell development and functional diversity …
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets
EC Josefsson, C James, KJ Henley… - Journal of Experimental …, 2011 - rupress.org
It is believed that megakaryocytes undergo a specialized form of apoptosis to shed platelets.
Conversely, a range of pathophysiological insults, including chemotherapy, are thought to …
Conversely, a range of pathophysiological insults, including chemotherapy, are thought to …
DNA methylation at enhancers identifies distinct breast cancer lineages
Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how
these affect the transcriptome and which changes are linked to transformation or …
these affect the transcriptome and which changes are linked to transformation or …