Abstract The United States Food and Drug Administration (US FDA) has always been a
forerunner in drug evaluation and supervision. Over the past 31 years, 1050 drugs …

This article reviews genes and syndromes associated with predisposition to colorectal
cancer (CRC), with an overview of gene variant classification. We include updates on the …

The prostanoids are a family of lipid mediators generated by the action of cyclooxygenase
on a 20-carbon unsaturated fatty acid, arachidonic acid. Prostanoids are generated widely in …

Resistance to apoptosis is closely linked to tumorigenesis, as it enables malignant cells to
expand even in a stressful environment. Cells resistant to apoptosis are also assumed to be …

Abstract Overexpression of cyclooxygenase 2 (COX2) and uncontrolled wingless and Int
(Wnt)-signaling pathway have long been suggested to play crucial roles in colorectal cancer …

CD11b+ myeloid subpopulations, including myeloid-derived suppressor cells (MDSCs) and
tumor-associated macrophages (TAMs), play crucial roles in the suppression of T-cell …

Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a
critical role during growth and metastasis of malignant tumors. Tumors exhibit significant …

Background Colorectal cancer can be efficiently treated when found at early stages, thus the
search for novel markers is of paramount importance. Since inflammation is associated with …

Chronic exposure to carcinogens represents the major risk factor for head and neck
squamous cell carcinoma (HNSCC). Beverages derived from broccoli sprout extracts (BSE) …

Chronic inflammation is involved in the pathogenesis of most common cancers. The
aetiology of the inflammation is varied and includes microbial, chemical and physical …