Venomous snakebite is considered the single most important cause of human injury from
venomous animals worldwide. Coagulopathy is one of the commonest important systemic …

Toxins from Bothrops venoms targeting hemostasis are responsible for a broad range of
clinical and biological syndromes including local and systemic bleeding, incoagulability …

Bothrops asper inflicts the majority of snakebites in Central America and in the northern
regions of South America, mostly affecting young agricultural workers in rural settings. This …

Hematologic abnormalities are the most common effects of snake envenoming globally.
Venom-induced consumption coagulopathy (VICC) is the commonest and most important …

Snake antivenoms are formulations of immunoglobulins, or immunoglobulin fragments,
purified from the plasma of animals immunized with snake venoms. Their therapeutic …

Envenomations by Bothrops asper are often associated with complex and severe local
pathological manifestations, including edema, blistering, dermonecrosis, myonecrosis and …

The parenteral administration of antivenoms is the cornerstone of snakebite envenoming
therapy. Efforts are made to ensure that antivenoms of adequate efficacy and safety are …

The therapy of snakebite envenomation has been based on the parenteral administration of
animal-derived antivenoms. Despite the success of this treatment at reducing the impact of …

Snakebite envenoming is a major cause of morbidity and mortality in rural communities
throughout the tropics. Generally, the main clinical features of snakebites are local swelling …

Moderate and severe envenomations by the snake Bothrops asper provoke systemic
alterations, such as systemic bleeding, coagulopathy, hypovolemia, hemodynamic instability …