The aminoacyl-tRNA synthetases are an essential and universally distributed family of
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …

Correct expression of the genetic code at translation is directly correlated with tRNA identity.
This survey describes the molecular signals in tRNAs that trigger specific aminoacylations …

RNA helical oligonucleotides that recapitulate the acceptor stems of transfer RNAs, and that
are devoid of the anticodon trinucleotides of the genetic code, are aminoacylated by …

1Current usage provides at least two alternative nomenclatures for these enzymes. The
more widely used convention combines the three-letter amino acid abbreviation with the …

Accurate translation of mRNA into protein is vital for maintenance of cellular integrity.
Translational fidelity is achieved by two key events: synthesis of correctly paired aminoacyl …

The aminoacyl‐tRNA synthetases are an ancient group of enzymes that catalyze the
covalent attachment of an amino acid to its cognate transfer RNA. The question of specificity …

Publisher Summary This chapter discusses the role of tRNA structure in the recognition
process with synthetases and on the implications for aminoacylation efficiency. Many …

The coding coenzyme handle hypothesis suggests that useful coding preceded translation.
Early adapters, the ancestors of present-day anticodons, were charged with amino acids …

Ligation of tRNAs with their cognate amino acids, by aminoacyl-tRNA synthetases,
establishes the genetic code. Throughout evolution, tRNAAla selection by alanyl-tRNA …

Correct recognition of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases is central to
the maintenance of translational fidelity. The hypothesis that synthetases recognize …