STAT3 signaling in immunity
EJ Hillmer, H Zhang, HS Li, SS Watowich - Cytokine & growth factor …, 2016 - Elsevier
The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
tissue function including control of inflammation and immunity. Mutations in human STAT3 …
The pathophysiology of anaphylaxis
Anaphylaxis is a severe systemic hypersensitivity reaction that is rapid in onset;
characterized by life-threatening airway, breathing, and/or circulatory problems; and usually …
characterized by life-threatening airway, breathing, and/or circulatory problems; and usually …
Targeting janus kinases and signal transducer and activator of transcription 3 to treat inflammation, fibrosis, and cancer: rationale, progress, and caution
U Bharadwaj, MM Kasembeli, P Robinson… - Pharmacological …, 2020 - ASPET
Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
Primary immunodeficiency diseases: genomic approaches delineate heterogeneous Mendelian disorders
A Stray-Pedersen, HS Sorte, P Samarakoon… - Journal of Allergy and …, 2017 - Elsevier
Background Primary immunodeficiency diseases (PIDDs) are clinically and genetically
heterogeneous disorders thus far associated with mutations in more than 300 genes. The …
heterogeneous disorders thus far associated with mutations in more than 300 genes. The …
STAT3 hyper-IgE syndrome—an update and unanswered questions
C Tsilifis, AF Freeman, AR Gennery - Journal of Clinical Immunology, 2021 - Springer
The hyper-IgE syndromes (HIES) are a heterogeneous group of inborn errors of immunity
sharing manifestations including increased infection susceptibility, eczema, and raised …
sharing manifestations including increased infection susceptibility, eczema, and raised …
DOCK8 deficiency: insights into pathophysiology, clinical features and management
Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency
that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending …
that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending …
Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment
Background Identifying genetic syndromes that lead to significant atopic disease can open
new pathways for investigation and intervention in allergy. Objective We sought to define a …
new pathways for investigation and intervention in allergy. Objective We sought to define a …
Hyper IgE syndromes: clinical and molecular characteristics
T Al‐Shaikhly, HD Ochs - Immunology and cell biology, 2019 - Wiley Online Library
Hyper IgE syndromes comprise a group of rare primary immunodeficiency disorders
characterized by a triad of atopic dermatitis, recurrent skin and lung infections along with …
characterized by a triad of atopic dermatitis, recurrent skin and lung infections along with …
Molecular mechanisms of cutaneous inflammatory disorder: atopic dermatitis
JE Kim, JS Kim, DH Cho, HJ Park - International journal of molecular …, 2016 - mdpi.com
Atopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions
between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly …
between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly …
The ying and yang of STAT3 in human disease
The transcription factor signal transducer and activator of transcription 3 (STAT3) is a critical
regulator of multiple, diverse cellular processes. Heterozgyous, germline, loss-of-function …
regulator of multiple, diverse cellular processes. Heterozgyous, germline, loss-of-function …