Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in
retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct …

Olfactory receptor (OR) genes are the largest gene superfamily in vertebrates. We have
identified the mouse OR genes from the nearly complete Celera mouse genome by a …

Mice, and cattle with mutations in the myostatin (GDF8) gene show a marked increase in
body weight and muscle mass, indicating that this new member of the TGF-β superfamily is a …

Odor signals received by odorant receptors (ORs) expressed by olfactory sensory neurons
(OSNs) in the olfactory epithelium (OE) are represented as an odor map in the olfactory bulb …

Young neurons born in the subventricular zone (SVZ) of adult mice migrate to the olfactory
bulb (OB) where they differentiate into granule cells (GCs) and periglomerular interneurons …

The chemical senses (smell and taste) have evolved complex repertoires of chemosensory
receptors—G-protein coupled receptors with a seven-transmembrane domain structure. In …

We investigate how the molecular and cellular maps of the Drosophila olfactory system are
integrated. A correspondence is established between individual odor receptors, neurons …

The rules by which neuronal activity causes long-term modification of synapses in the
central nervous system are not fully understood. Whereas competitive or correlation-based …

In the fruit fly, Drosophila, olfactory sensory neurons expressing a given receptor project to
spatially invariant loci in the antennal lobe to create a topographic map of receptor …