Polyphenols: multipotent therapeutic agents in neurodegenerative diseases
KS Bhullar, HPV Rupasinghe - Oxidative medicine and cellular …, 2013 - Wiley Online Library
Aging leads to numerous transitions in brain physiology including synaptic dysfunction and
disturbances in cognition and memory. With a few clinically relevant drugs, a substantial …
disturbances in cognition and memory. With a few clinically relevant drugs, a substantial …
Cellular and molecular mechanisms of prion disease
Prion diseases are rapidly progressive, incurable neurodegenerative disorders caused by
misfolded, aggregated proteins known as prions, which are uniquely infectious. Remarkably …
misfolded, aggregated proteins known as prions, which are uniquely infectious. Remarkably …
The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases
Aging, a fundamental physiological process influenced by innumerable biological and
genetic pathways, is an important driving factor for several aging‐associated disorders like …
genetic pathways, is an important driving factor for several aging‐associated disorders like …
[HTML][HTML] The Interplay between Ca2+ Signaling Pathways and Neurodegeneration
RP Ureshino, AG Erustes, TB Bassani… - International journal of …, 2019 - mdpi.com
Calcium (Ca2+) homeostasis is essential for cell maintenance since this ion participates in
many physiological processes. For example, the spatial and temporal organization of Ca2+ …
many physiological processes. For example, the spatial and temporal organization of Ca2+ …
The essential role of soluble Aβ oligomers in Alzheimer's disease
ZX Wang, L Tan, J Liu, JT Yu - Molecular neurobiology, 2016 - Springer
Alzheimer's disease (AD) is a common neurodegenerative disease characterized by
amyloid plaque and neurofibrillary tangles (NFT). With the finding that soluble nonfibrillar Aβ …
amyloid plaque and neurofibrillary tangles (NFT). With the finding that soluble nonfibrillar Aβ …
Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment
M Zhou, G Ottenberg, GF Sferrazza, C Hubbs, M Fallahi… - Brain, 2015 - academic.oup.com
The mechanisms of neuronal death in protein misfolding neurodegenerative diseases such
as Alzheimer's, Parkinson's and prion diseases are poorly understood. We used a highly …
as Alzheimer's, Parkinson's and prion diseases are poorly understood. We used a highly …
[HTML][HTML] The N-terminus of the prion protein is a toxic effector regulated by the C-terminus
B Wu, AJ McDonald, K Markham, CB Rich, KP McHugh… - Elife, 2017 - elifesciences.org
PrPC, the cellular isoform of the prion protein, serves to transduce the neurotoxic effects of
PrPSc, the infectious isoform, but how this occurs is mysterious. Here, using a combination …
PrPSc, the infectious isoform, but how this occurs is mysterious. Here, using a combination …
Second sphere interactions in amyloidogenic diseases
Amyloids are protein aggregates bearing a highly ordered cross β structural motif, which
may be functional but are mostly pathogenic. Their formation, deposition in tissues and …
may be functional but are mostly pathogenic. Their formation, deposition in tissues and …
Mechanisms of prion-induced toxicity
RCC Mercer, DA Harris - Cell and Tissue Research, 2023 - Springer
Prion diseases are devastating neurodegenerative diseases caused by the structural
conversion of the normally benign prion protein (PrPC) to an infectious, disease-associated …
conversion of the normally benign prion protein (PrPC) to an infectious, disease-associated …
[HTML][HTML] Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity
SAG Black, PK Stys, GW Zamponi… - Frontiers in cell and …, 2014 - frontiersin.org
Although it is well established that misfolding of the cellular prion protein (PrPC) into the β-
sheet-rich, aggregated scrapie conformation (PrPSc) causes a variety of transmissible …
sheet-rich, aggregated scrapie conformation (PrPSc) causes a variety of transmissible …