Aging leads to numerous transitions in brain physiology including synaptic dysfunction and
disturbances in cognition and memory. With a few clinically relevant drugs, a substantial …

Prion diseases are rapidly progressive, incurable neurodegenerative disorders caused by
misfolded, aggregated proteins known as prions, which are uniquely infectious. Remarkably …

Calcium (Ca2+) homeostasis is essential for cell maintenance since this ion participates in
many physiological processes. For example, the spatial and temporal organization of Ca2+ …

Aging, a fundamental physiological process influenced by innumerable biological and
genetic pathways, is an important driving factor for several aging‐associated disorders like …

Amyloids are protein aggregates bearing a highly ordered cross β structural motif, which
may be functional but are mostly pathogenic. Their formation, deposition in tissues and …

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by
amyloid plaque and neurofibrillary tangles (NFT). With the finding that soluble nonfibrillar Aβ …

The mechanisms of neuronal death in protein misfolding neurodegenerative diseases such
as Alzheimer's, Parkinson's and prion diseases are poorly understood. We used a highly …

PrPC, the cellular isoform of the prion protein, serves to transduce the neurotoxic effects of
PrPSc, the infectious isoform, but how this occurs is mysterious. Here, using a combination …

Prion diseases are devastating neurodegenerative diseases caused by the structural
conversion of the normally benign prion protein (PrPC) to an infectious, disease-associated …

Although it is well established that misfolding of the cellular prion protein (PrPC) into the β-
sheet-rich, aggregated scrapie conformation (PrPSc) causes a variety of transmissible …