[HTML][HTML] MicroRNAs as modulators and biomarkers of inflammatory and neuropathic pain conditions

HH Andersen, M Duroux, P Gazerani - Neurobiology of Disease, 2014 - Elsevier
The post-transcriptional regulator molecules, microRNAs, have emerged as important
biomarkers and modulators of numerous pathophysiological processes including …

Epigenetic regulation of chronic pain

L Liang, BM Lutz, A Bekker, YX Tao - Epigenomics, 2015 - Taylor & Francis
Chronic pain arising from peripheral inflammation and tissue or nerve injury is a common
clinical symptom. Although intensive research on the neurobiological mechanisms of …

[HTML][HTML] A nerve injury–specific long noncoding RNA promotes neuropathic pain by increasing Ccl2 expression

S Du, S Wu, X Feng, B Wang, S Xia… - The Journal of …, 2022 - Am Soc Clin Investig
Maladaptive changes of nerve injury–associated genes in dorsal root ganglia (DRGs) are
critical for neuropathic pain genesis. Emerging evidence supports the role of long noncoding …

[HTML][HTML] DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons

JY Zhao, L Liang, X Gu, Z Li, S Wu, L Sun… - Nature …, 2017 - nature.com
Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons,
which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses …

N6‐Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons

Y Li, X Guo, L Sun, J Xiao, S Su, S Du, Z Li… - Advanced …, 2020 - Wiley Online Library
Nerve injury‐induced change in gene expression in primary sensory neurons of dorsal root
ganglion (DRG) is critical for neuropathic pain genesis. N6‐methyladenosine (m6A) …

Downregulation of a dorsal root ganglion‐specifically enriched long noncoding RNA is required for neuropathic pain by negatively regulating RALY‐triggered Ehmt2 …

Z Pan, S Du, K Wang, X Guo, Q Mao, X Feng… - Advanced …, 2021 - Wiley Online Library
Nerve injury‐induced maladaptive changes of gene expression in dorsal root ganglion
(DRG) neurons contribute to neuropathic pain. Long non‐coding RNAs (lncRNAs) are …

Long noncoding RNA (lncRNA): a target in neuropathic pain

S Wu, J Bono, YX Tao - Expert opinion on therapeutic targets, 2019 - Taylor & Francis
Introduction: Current treatments for neuropathic pain are limited in part due to the incomplete
understanding of its underlying mechanisms. Recent evidence reveals the dysregulated …

Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3. 2 channels

R Qi, J Cao, Y Sun, Y Li, Z Huang… - Proceedings of the …, 2022 - National Acad Sciences
microRNA (miRNA)–mediated gene regulation has been studied as a therapeutic approach,
but its functional regulatory mechanism in neuropathic pain is not well understood. Here, we …

Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1. 2 expression in primary sensory neurons

Y Liang, D Sharma, B Wang, H Wang, X Feng… - Translational …, 2024 - Elsevier
Nerve injury-induced alternations of gene expression in primary sensory neurons of the
dorsal root ganglion (DRG) are molecular basis of neuropathic pain genesis. Transcription …

[HTML][HTML] The importance of the gut microbiome and its signals for a healthy nervous system and the multifaceted mechanisms of neuropsychiatric disorders

L Riehl, J Fürst, M Kress, N Rykalo - Frontiers in Neuroscience, 2024 - frontiersin.org
Increasing evidence links the gut microbiome and the nervous system in health and disease.
This narrative review discusses current views on the interaction between the gut microbiota …