Melatonin is a ubiquitous indolamine, largely investigated for its key role in the regulation of
several physiological processes in both animals and plants. In the last century, it was …

Background Melatonin is an indole hormone secreted primarily by the pineal gland that
showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity. It can play an important …

A dose-response relationship to stressors, according to the hormesis theory, is characterized
by low-dose stimulation and high-dose inhibition. It is non-linear with a low-dose optimum …

Environmental risk factors, including noise, air pollution, chemical agents, ultraviolet
radiation (UVR) and mental stress have a considerable impact on human health. Oxidative …

The concept of “aging” is defined as the set of gradual and progressive changes in an
organism that leads to an increased risk of weakness, disease, and death. This process may …

Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial
cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome - PMC …

Chronic arsenic (As) exposure, mainly as a result of drinking contaminated water, is
associated with cardiovascular diseases. Mitochondrial dysfunction, oxidative stress …

Background: Spinal cord injury (SCI) is a central nervous system (CNS) trauma involving
inflammation and oxidative stress, which play important roles in this trauma's pathogenesis …

One of the causes of intervertebral disc degeneration (IVDD) is nucleus pulposus cell (NPC)
death, possibly apoptosis. In this study, we explored the role of the Nrf2/Sirt3 pathway and …

Grape seed proanthocyanidin extract (GSPE) that prevents and alleviates the degenerative
changes associated with aging has been receiving extensive attention. In our present work …