Antibiotic perturbations to the gut microbiome

SRS Fishbein, B Mahmud, G Dantas - Nature Reviews Microbiology, 2023 - nature.com
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Advances in drug delivery systems, challenges and future directions

TC Ezike, US Okpala, UL Onoja, CP Nwike, EC Ezeako… - Heliyon, 2023 - cell.com
Advances in molecular pharmacology and an improved understanding of the mechanism of
most diseases have created the need to specifically target the cells involved in the initiation …

Evolution of drug delivery systems: From 1950 to 2020 and beyond

H Park, A Otte, K Park - Journal of Controlled Release, 2022 - Elsevier
Modern drug delivery technology began in 1952 with the advent of the Spansule® sustained-
release capsule technology, which can deliver a drug for 12 h after oral administration …

[HTML][HTML] Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

LE McCoubrey, A Favaron, A Awad, M Orlu… - Journal of Controlled …, 2023 - Elsevier
Colonic drug delivery can facilitate access to unique therapeutic targets and has the
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …

Connected healthcare: Improving patient care using digital health technologies

A Awad, SJ Trenfield, TD Pollard, JJ Ong… - Advanced Drug Delivery …, 2021 - Elsevier
Now more than ever, traditional healthcare models are being overhauled with digital
technologies of Healthcare 4.0 increasingly adopted. Worldwide, digital devices are …

Harnessing artificial intelligence for the next generation of 3D printed medicines

M Elbadawi, LE McCoubrey, FKH Gavins… - Advanced Drug Delivery …, 2021 - Elsevier
Artificial intelligence (AI) is redefining how we exist in the world. In almost every sector of
society, AI is performing tasks with super-human speed and intellect; from the prediction of …

Let's talk about sex: Differences in drug therapy in males and females

CM Madla, FKH Gavins, HA Merchant, M Orlu… - Advanced drug delivery …, 2021 - Elsevier
Abstract Professor Henry Higgins in My Fair Lady said,'Why can'ta woman be more like a
man?'Perhaps unintended, such narration extends to the reality of current drug …

Mechanisms of peripheral levodopa resistance in Parkinson's disease

M Beckers, BR Bloem, MM Verbeek - npj Parkinson's Disease, 2022 - nature.com
Parkinson's disease (PD) is an increasingly common neurodegenerative condition. The
disease has a significant negative impact on quality of life, but a personalized management …

pH-responsive drug delivery systems as intelligent carriers for targeted drug therapy: Brief history, properties, synthesis, mechanism and application

MS Bami, MAR Estabragh, P Khazaeli, M Ohadi… - Journal of Drug Delivery …, 2022 - Elsevier
There are different pH-sensitive systems for biomedical applications that have recently been
considered for pH targeting nanomedicine. In this review, we examine some of the most …

Predicting drug-microbiome interactions with machine learning

LE McCoubrey, S Gaisford, M Orlu, AW Basit - Biotechnology advances, 2022 - Elsevier
Pivotal work in recent years has cast light on the importance of the human microbiome in
maintenance of health and physiological response to drugs. It is now clear that …