Recent advances in chromatography for pharmaceutical analysis
The pharmaceutical industry is one of the most regulated industries worldwide, since the
drug products have to be safe and effective. The levels of impurities and degradation …
drug products have to be safe and effective. The levels of impurities and degradation …
Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications
Over the past few years, loss of patent protection for blockbuster monoclonal antibody (mAb)
drugs has caused a significant shift in the pharmaceutical industry towards the development …
drugs has caused a significant shift in the pharmaceutical industry towards the development …
Prediction of analyte retention time in liquid chromatography
Scope and Layout of This Review. This review addresses the approaches used to predict
chromatographic retention time in a range of liquid chromatographic techniques, with a …
chromatographic retention time in a range of liquid chromatographic techniques, with a …
Development of comprehensive online two-dimensional liquid chromatography/mass spectrometry using hydrophilic interaction and reversed-phase separations for …
Monoclonal antibodies (mAb) and related molecules are being developed at a remarkable
pace as new therapeutics for the treatment of diseases ranging from cancer to inflammatory …
pace as new therapeutics for the treatment of diseases ranging from cancer to inflammatory …
Computer-assisted multifactorial method development for the streamlined separation and analysis of multicomponent mixtures in (Bio) pharmaceutical settings
The (bio) pharmaceutical industry is rapidly moving towards complex drug modalities that
require a commensurate level of analytical enabling technologies that can be deployed at a …
require a commensurate level of analytical enabling technologies that can be deployed at a …
Hydrophilic interaction chromatography for the analysis of biopharmaceutical drugs and therapeutic peptides: A review based on the separation characteristics of the …
T Ikegami - Journal of separation science, 2019 - Wiley Online Library
Applications of hydrophilic interaction chromatography for the analysis of biopharmaceutical
drugs, ie, glycosylated proteins represented by monoclonal antibodies are discussed in the …
drugs, ie, glycosylated proteins represented by monoclonal antibodies are discussed in the …
Exosome isolation and purification via hydrophobic interaction chromatography using a polyester, capillary‐channeled polymer fiber phase
Extracellular vesicles, including microvesicles and exosomes, are lipidic membrane‐derived
vesicles that are secreted by most cell types. Exosomes, one class of these vesicles that are …
vesicles that are secreted by most cell types. Exosomes, one class of these vesicles that are …
Cutting-edge multi-level analytical and structural characterization of antibody-drug conjugates: present and future
Introduction: The development and optimization of antibody drug conjugates (ADCs) rely on
improving their analytical and bioanalytical characterization, by assessing critical quality …
improving their analytical and bioanalytical characterization, by assessing critical quality …
Recent development in hydrophilic interaction liquid chromatography stationary materials for glycopeptide analysis
Protein glycosylation is one of the most important post-translational modifications, and
aberrant glycosylation is associated with the occurrence and development of diseases …
aberrant glycosylation is associated with the occurrence and development of diseases …
Quantitative N-Glycan Profiling of Therapeutic Monoclonal Antibodies Performed by Middle-Up Level HILIC-HRMS Analysis
The identification and accurate quantitation of the various glycoforms contained in
therapeutic monoclonal antibodies (mAbs) is one of the main analytical needs in the …
therapeutic monoclonal antibodies (mAbs) is one of the main analytical needs in the …