Inflammatory bowel disease in pregnancy and breastfeeding

MN Brondfield, U Mahadevan - Nature Reviews Gastroenterology & …, 2023 - nature.com
Inflammatory bowel disease (IBD) has a peak age of diagnosis before the age of 35 years.
Concerns about infertility, adverse pregnancy outcomes, and heritability of IBD have …

European Crohn's and colitis guidelines on sexuality, fertility, pregnancy, and lactation

J Torres, M Chaparro, M Julsgaard… - Journal of Crohn's …, 2023 - academic.oup.com
2. Methods This document represents the third version of the European Consensus on
reproduction in IBD. The development of this Consensus included the formulation of …

New drugs for the treatment of IBD during conception, pregnancy, and lactation

D Pugliese, G Privitera, JP Gisbert… - Digestive and Liver …, 2024 - Elsevier
The management of inflammatory bowel disease requires continuous medical therapy to
achieve and maintain disease control. Thus, women can be exposed to different drugs …

Safety of ustekinumab and vedolizumab during pregnancy—pregnancy, neonatal, and infant outcome: A prospective multicentre study

K Mitrova, B Pipek, M Bortlik, L Bouchner… - Journal of Crohn's …, 2022 - academic.oup.com
Abstract Background and Aims Evidence on the safety of newer biologics during pregnancy
is limited. We aimed to assess the safety of ustekinumab and vedolizumab treatment during …

[HTML][HTML] Infant ustekinumab clearance, risk of infection, and development after exposure during pregnancy

M Julsgaard, JW Wieringa, SMD Baunwall… - Clinical …, 2025 - Elsevier
Background Evidence on ustekinumab safety in pregnancy is gradually expanding, but its
clearance in the postnatal period is unknown. The aim of this study was to investigate …

Pregnancy outcomes following periconceptional or gestational exposure to ustekinumab: Review of cases reported to the manufacturer's global safety database

U Mahadevan, S Naureckas, I Tikhonov… - Alimentary …, 2022 - Wiley Online Library
Background Ustekinumab, a human immunoglobulin G1 monoclonal antibody that binds to
and inhibits interleukin (IL)‐12/IL‐23, is indicated for multiple immune‐mediated diseases …

Vedolizumab and ustekinumab levels in pregnant women with inflammatory bowel disease and infants exposed in utero

R Prentice, E Flanagan, EK Wright, PR Gibson… - Clinical …, 2025 - Elsevier
Background & Aims Vedolizumab and ustekinumab pharmacokinetics in pregnancy and the
infant after in utero exposure remain incompletely defined. We aim to define the antenatal …

Australian inflammatory bowel disease consensus statements for preconception, pregnancy and breast feeding

R Laube, CP Selinger, CH Seow, B Christensen… - Gut, 2023 - gut.bmj.com
Objective Because pregnancy outcomes tend to be worse in women with inflammatory
bowel disease (IBD) than in those without, we aimed to update consensus statements that …

Vaccines in Children Exposed to Biological Agents In Utero and/or During Breastfeeding: Are They Effective and Safe?

JP Gisbert, M Chaparro - Journal of Crohn's and Colitis, 2023 - academic.oup.com
Background Biological agents cross the placenta, resulting in detectable blood levels in the
neonate. Neonatal vaccinations are essential to prevent serious infections. Aim To review …

Maternal and Neonatal Outcomes in Vedolizumab-and Ustekinumab-Exposed Pregnancies: Results From the PIANO Registry

R Chugh, MD Long, Y Jiang, KN Weaver… - Official journal of the …, 2022 - journals.lww.com
Background: Pregnancy outcomes in patients with inflammatory bowel disease with
quiescent disease are similar to those in the general population. Data from the Pregnancy …