Clear cell renal cell carcinomas (ccRCCs) represent∼ 75% of RCC cases and account for
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …

To improve the understanding of chemo-refractory high-grade serous ovarian cancers
(HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) …

Targeted therapies are effective in treating cancer, but success depends on identifying
cancer vulnerabilities. In our study, we utilize small RNA sequencing to examine the impact …

Cancer originates from somatic cells that have accumulated mutations. These mutations
alter the phenotype of the cells, allowing them to escape homeostatic regulation that …

Summary Plakophilin 3 (PKP3) is a component of desmosomes and is frequently
overexpressed in cancer. Using keratinocytes either lacking or overexpressing PKP3, we …

Identifying cancer genes is vital for cancer diagnosis and treatment. However, because of
the complexity of cancer occurrence and limited cancer genes knowledge, it is hard to …

Analyzing highly individual-specific genomic data to understand genetic interactions in
cancer development is still challenging, with significant implications for the discovery of …

By using metaproteomics of the human colonic mucosal surface, we found evidence for a
proteomic ecology of millimeter-scale protein networks distinguished by functional …