Retinal photoreceptor cells contain a specialized outer segment (OS) compartment that
functions in the capture of light and its conversion into electrical signals in a process known …

Cilia are hair-like projections found on almost all cells in the human body. Originally
believed to function merely in motility, the function of solitary non-motile (primary) cilia was …

The dynamic localization of proteins within cells is often determined by environmental
stimuli. In retinal photoreceptors, light exposure results in the massive translocation of three …

The light-sensing organelle of the vertebrate rod photoreceptor, the outer segment (OS), is a
modified cilium containing∼ 1,000 stacked disc membranes that are densely packed with …

Background: Arrestins are pivotal, multifunctional organizers of cell responses to GPCR
stimulation, including cell survival and cell death. In Drosophila norpA and rdgC mutants …

Light induces massive translocation of major signaling proteins between the subcellular
compartments of photoreceptors. Among them is visual arrestin responsible for quenching …

Functional compartmentalization of cells is a universal strategy for segregating processes
that require specific components, undergo regulation by modulating concentrations of those …

Intraflagellar Transport (IFT) refers to a highly conserved process occurring in eukaryotic
ciliated structures. In vertebrate photoreceptors, IFT mediates protein trafficking to the outer …

Purpose: To determine the temporal kinetics of the simultaneous translocation of arrestin
and rod α-transducin in mice exposed to different lighting environments and to compare the …

Visual arrestin plays a crucial role in the termination of the light response in vertebrate
photoreceptors by binding selectively to light-activated, phosphorylated rhodopsin. Arrestin …