Genetic and biological hallmarks of colorectal cancer
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …
tumors, and these insights have illuminated early detection, risk stratification, prevention …
[HTML][HTML] Functions and dysfunctions of nitric oxide in brain
P Picón-Pagès, J Garcia-Buendia, FJ Munoz - Biochimica et Biophysica …, 2019 - Elsevier
Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …
flow and also has important roles in intracellular signaling in neurons from the regulation of …
[HTML][HTML] Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
DS Simpson, J Pang, A Weir, IY Kong, M Fritsch… - Immunity, 2022 - cell.com
Cell death plays an important role during pathogen infections. Here, we report that interferon-
γ (IFNγ) sensitizes macrophages to Toll-like receptor (TLR)-induced death that requires …
γ (IFNγ) sensitizes macrophages to Toll-like receptor (TLR)-induced death that requires …
[HTML][HTML] The dual role of iNOS in cancer
Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous
free radical whose predominant functions is that of a messenger through cGMP. In …
free radical whose predominant functions is that of a messenger through cGMP. In …
Nitric oxide and its derivatives in the cancer battlefield
A Kamm, P Przychodzen, A Kuban-Jankowska… - Nitric oxide, 2019 - Elsevier
Elevated levels of reactive nitrogen species, alteration in redox balance and deregulated
redox signaling are common hallmarks of cancer progression and chemoresistance …
redox signaling are common hallmarks of cancer progression and chemoresistance …
[HTML][HTML] Oxidants, antioxidants and thiol redox switches in the control of regulated cell death pathways
M Benhar - Antioxidants, 2020 - mdpi.com
It is well appreciated that biological reactive oxygen and nitrogen species such as hydrogen
peroxide, superoxide and nitric oxide, as well as endogenous antioxidant systems, are …
peroxide, superoxide and nitric oxide, as well as endogenous antioxidant systems, are …
CD36-and GPR120-mediated Ca2+ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice
Background & Aims It is important to increase our understanding of gustatory detection of
dietary fat and its contribution to fat preference. We studied the roles of the fat taste receptors …
dietary fat and its contribution to fat preference. We studied the roles of the fat taste receptors …
Protein S-Nitrosation: Biochemistry, Identification, Molecular Mechanisms, and Therapeutic Applications
H Ye, J Wu, Z Liang, Y Zhang… - Journal of Medicinal …, 2022 - ACS Publications
Protein S-nitrosation (SNO), a posttranslational modification (PTM) of cysteine (Cys)
residues elicited by nitric oxide (NO), regulates a wide range of protein functions. As a …
residues elicited by nitric oxide (NO), regulates a wide range of protein functions. As a …
[HTML][HTML] S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95
PSD-95, a principal scaffolding component of the postsynaptic density, is targeted to
synapses by palmitoylation, where it couples NMDA receptor stimulation to production of …
synapses by palmitoylation, where it couples NMDA receptor stimulation to production of …
Primary and Secondary Coordination Sphere Effects on the Structure and Function of S-Nitrosylating Azurin
Much progress has been made in understanding the roles of the secondary coordination
sphere (SCS) in tuning redox potentials of metalloproteins. In contrast, the impact of SCS on …
sphere (SCS) in tuning redox potentials of metalloproteins. In contrast, the impact of SCS on …