Chronic obstructive pulmonary disease (COPD) is a major respiratory illness in Canada that
is both preventable and treatable. Our understanding of the pathophysiology of this complex …

Context The care of patients with chronic obstructive pulmonary disease (COPD) has
changed radically over the past 2 decades, and novel therapies can not only improve the …

Although long-acting bronchodilators have been an important advance for the management
of chronic obstructive pulmonary disease (COPD), these drugs do not deal with the …

Advanced emphysema is a lung disease in which alveolar capillary units are destroyed and
supporting tissue is lost. The combined effect of reduced gas exchange and changes in …

Background Severe emphysema is a debilitating condition with few treatment options. Lung
volume reduction procedures in the treatment of severe emphysema have shown excellent …

OBJECTIVES: Minimally invasive endoscopic treatment of emphysema could provide
palliation with less risk than lung volume reduction surgery and offer therapy to patients …

Background Lung volume reduction surgery (LVRS) performed to treat patients with severe
diffuse emphysema was reintroduced in the nineties. Lung volume reduction surgery aims to …

Objective: To assess the feasibility, safety, and early results of awake lung volume reduction
surgery (LVRS) performed under thoracic epidural anesthesia by a new nonresectional …

Lung volume reduction surgery (LVRS) produces physiological, symptomatic, and survival
benefits in selected patients with advanced emphysema. Because it is associated with …

Background Assessment of health-related quality of life (HRQL) is important in patients with
chronic obstructive pulmonary disease (COPD). Despite the high prevalence of COPD in …