Growing evidence suggests that vitamin C supplementation may be an effective adjunct
therapy in the management of people with diabetes. This paper critically reviews the current …

Garrod's concept of 'chemical individuality'has contributed to comprehension of the
molecular origins of human diseases. Untargeted high-throughput metabolomic …

WNT signaling promotes the initiation and progression of pancreatic ductal adenocarcinoma
(PDAC) through wide-ranging effects on cellular proliferation, survival, differentiation …

Background Micronutrients, namely vitamins and minerals, are associated with cancer
outcomes; however, their reported effects have been inconsistent across studies. We aimed …

Background Micronutrients play an essential role at every stage of the immune response,
and deficiencies can therefore lead to increased susceptibility to infections. Previous …

Broad-capture proteomic platforms now enable simultaneous assessment of thousands of
plasma proteins, but most of these are not actively secreted and their origins are largely …

Background Circulating vitamin C concentrations have been associated with several
cancers in observational studies, but little is known about the causal direction of the …

Background Evidence for antioxidants, minerals and vitamins in relation to the risk of
Crohn's disease (CD) and ulcerative colitis (UC) is limited and inconsistent. This mendelian …

Background Whether supplementation with diet-derived antioxidants is beneficial for
nonalcoholic fatty liver disease (NAFLD) is still controversial and we hope to answer this …

Given the strong association between obesity and endometrial cancer risk, dietary factors
may play an important role in the development of this cancer. However, observational …