It is broadly acknowledged that the onset of dementia in Alzheimer's disease (AD) may be
modifiable by the management of risk factors. While several recent guidelines and …

The brain is the key organ of the response to stress because it determines what is
threatening and, therefore, potentially stressful, as well as the physiological and behavioral …

Major depressive disorder (MDD) is characterized by structural and neurochemical changes
in limbic structures, including the hippocampus, that regulate mood and cognitive functions …

Accumulating evidence implicates hippocampal neurogenesis in the pathophysiology of
depression. Psychosocial stress reduces neurogenesis in rodents, whereas chronic …

The adult brain is much more resilient and adaptable than previously believed, and adaptive
structural plasticity involves growth and shrinkage of dendritic trees, turnover of synapses …

In normal life, organisms are repeatedly exposed to brief periods of stress, most of which can
be controlled and adequately dealt with. The presently available data indicate that such brief …

Purpose: Depression is one of the most prevalent, recurrent and life-threatening mental
illnesses. However, the precise mechanism underlying the disorder is not yet clearly …

Increasing number of studies has during the last decade linked neurotrophic factors with the
pathophysiology of neuropsychiatric disorders and with the mechanisms of action of drugs …

The adult brain is capable of considerable structural and functional plasticity and the study of
hormone actions in brain has contributed to our understanding of this important …

Antidepressants are commonly used in the treatment of anxiety and depression, medical
conditions that affect∼ 17–20% of the population. The clinical effects of antidepressants …