Alterations of the gut microbiota may cause dysregulated mucosal immune responses
leading to the onset of inflammatory bowel diseases (IBD) in genetically susceptible hosts …

Inflammatory bowel disease (IBD) is characterised by episodes of relapse and periods of
remission. However, the clinical features, such as abdominal pain, diarrhoea, and rectal …

2. Methods Based on the GRADE workflow, the Guidelines Committee of ECCO [GuiCom]
selected a panel of 48 experts supported by a team of methodologists and librarians …

This article is the second in a series of two publications relating to the European Crohn's and
Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn's …

Perianal fistulising Crohn's disease is an aggressive disease phenotype that can have a
substantial detrimental impact on patients' quality of life. Current biological understanding of …

Background Fistulas have puzzled us all the time and stem cell therapy for it is still in its
infancy. We conducted a meta-analysis and systematic review to evaluate the efficacy of …

Background & Aims Perianal fistulas are common in patients with Crohn's disease (CD).
Injections of cultured autologous and allogeneic adipose tissue-derived stem cells have …

Inflammatory bowel disease (IBD) has increased in incidence and prevalence in Asian
countries since the end of the 20th century. Moreover, differences in the cause, phenotypes …

Background Exosome administration is a novel medical approach that promises excellent
immunomodulatory properties without the conventional side effects of current antitumor …

Background Perianal fistulas, characterised as granulomatous inflammation of fistulas
around the anal canal, are associated with significant morbidity resulting in a negative …