The therapeutic onset of traditional antidepressants is delayed by several weeks and many
depressed patients fail to respond to treatment altogether. In contrast, subanesthetic …

Rationale We investigated the immediate and enduring effects of ketamine in behavioral
and neurochemical assays predictive of antidepressant activity. Materials and methods One …

Phencyclidine and ketamine (but not other NMDA channel blockers, such as memantine)
produce psychotomimetic effects. Since unlike memantine, phencyclidine-like compounds …

A growing body of evidence has pointed to the ionotropic glutamate N-methyl-d-aspartate
receptor (NMDA) as an important player in the etiology of psychopathologies, including …

Rationale Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by
intrusive obsessive thoughts and/or compulsive behaviors. Currently, serotonin reuptake …

The objective of the present study was to evaluate the antidepressant action of Withania
somnifera (WS) as well as its interaction with the conventional antidepressant drugs and to …

Thyroid dysfunction can compromise physical capacity. Here, we analyze the effects of
hyperthyroidism and hypothyroidism on maximum swim time in rats subjected to acute …

Ketamine rapidly alleviates symptoms of treatment-resistant major depression within hours
of a single administration. While this may offer a new and promising trajectory for novel …

Serotonin-1B receptors (5-HT1BRs), previously termed 5-HT1Dβ in humans [161], modulate
perseverative behaviors and prepulse inhibition (PPI) in humans [155, 206, 287, 338] and …

RESUMO A ovariectomia, extração dos ovários, contribui para a carência de estrogênio e
desta forma é um bom modelo para representar a diminuição deste hormônio que ocorre na …