Overcoming skin barriers through advanced transdermal drug delivery approaches

V Phatale, KK Vaiphei, S Jha, D Patil, M Agrawal… - Journal of controlled …, 2022 - Elsevier
Upon exhaustive research, the transdermal drug delivery system (TDDS) has appeared as a
potential, well-accepted, and popular approach to a novel drug delivery system. Ease of …

Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases

T Sakuragi, S Nagata - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

Design of liposomes as drug delivery system for therapeutic applications

D Guimarães, A Cavaco-Paulo, E Nogueira - International journal of …, 2021 - Elsevier
Liposomes are spherical vesicles consisting of one or more concentric phospholipid bilayers
enclosing an aqueous core. Being both nontoxic and biodegradable, liposomes represent a …

Nanomedicine review: Clinical developments in liposomal applications

E Beltrán-Gracia, A López-Camacho… - Cancer …, 2019 - Springer
Background In recent years, disease treatment has evolved strategies that require increase
in pharmaceutical agent's efficacy and selectivity while decreasing their toxicity in normal …

Understanding the diversity of membrane lipid composition

T Harayama, H Riezman - Nature reviews Molecular cell biology, 2018 - nature.com
Cellular membranes are formed from a chemically diverse set of lipids present in various
amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from …

The various roles of fatty acids

CCCR De Carvalho, MJ Caramujo - Molecules, 2018 - mdpi.com
Lipids comprise a large group of chemically heterogeneous compounds. The majority have
fatty acids (FA) as part of their structure, making these compounds suitable tools to examine …

Computational modeling of realistic cell membranes

SJ Marrink, V Corradi, PCT Souza, HI Ingolfsson… - Chemical …, 2019 - ACS Publications
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

Lipidomics for studying metabolism

X Han - Nature Reviews Endocrinology, 2016 - nature.com
Many thousands of lipid species exist and their metabolism is interwoven via numerous
pathways and networks. These networks can also change in response to cellular …

Membrane fission by dynamin: what we know and what we need to know

B Antonny, C Burd, P De Camilli, E Chen… - The EMBO …, 2016 - embopress.org
The large GTP ase dynamin is the first protein shown to catalyze membrane fission.
Dynamin and its related proteins are essential to many cell functions, from endocytosis to …

Membrane curvature at a glance

HT McMahon, E Boucrot - Journal of cell science, 2015 - journals.biologists.com
Membrane curvature is an important parameter in defining the morphology of cells,
organelles and local membrane subdomains. Transport intermediates have simpler shapes …