[HTML][HTML] Effects of histone modification in major depressive disorder

MS Wu, XJ Li, CY Liu, Q Xu, JQ Huang… - Current …, 2022 - ncbi.nlm.nih.gov
Major depressive disorder (MDD) is a disease associated with many factors; specifically,
environmental, genetic, psychological, and biological factors play critical roles. Recent …

Epigenetics: a link between addiction and social environment

DC Ajonijebu, O Abboussi, VA Russell… - Cellular and Molecular …, 2017 - Springer
The detrimental effects of drug abuse are apparently not limited to individuals but may also
impact the vulnerability of their progenies to develop addictive behaviours. Epigenetic …

Epigenetic programming by stress and glucocorticoids along the human lifespan

AS Zannas, GP Chrousos - Molecular psychiatry, 2017 - nature.com
Psychosocial stress triggers a set of behavioral, neural, hormonal, and molecular responses
that can be a driving force for survival when adaptive and time-limited, but may also …

Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex: an …

VV Reshetnikov, PE Kisaretova, NI Ershov… - Progress in Neuro …, 2021 - Elsevier
Chronic stress is the leading risk factor of a broad range of severe psychopathologies.
Nonetheless, the molecular mechanisms triggering these pathological processes are not …

Epigenetics of fear, anxiety and stress–focus on histone modifications

MA Ell, MA Schiele, N Iovino… - Current …, 2024 - benthamdirect.com
Fear-, anxiety-and stress-related disorders are among the most frequent mental disorders.
Given substantial rates of insufficient treatment response and often a chronic course, a better …

Oxytocin prevents the increase of cocaine-related responses produced by social defeat

C Ferrer-Pérez, A Castro-Zavala, MÁ Luján… - …, 2019 - Elsevier
The neuropeptide oxytocin (OXT) plays a critical role in the regulation of social and
emotional behaviors. OXT plays a role in stress response and in drug reward, but to date no …

Histone modifications in major depressive disorder and related rodent models

JM Deussing, M Jakovcevski - Neuroepigenomics in aging and disease, 2017 - Springer
Major depressive disorder (MDD) is a multifactorial disease, weakly linked to multiple
genetic risk factors. In contrast to that, environmental factors and “gene× environment” …

Psychostimulants and opioids differentially influence the epigenetic modification of histone acetyltransferase and histone deacetylase in astrocytes

M Doke, G Pendyala, T Samikkannu - PLoS One, 2021 - journals.plos.org
Illicit drugs are known to affect central nervous system (CNS). Majorly psychostimulants such
as cocaine, methamphetamine (METH) and opioids such as morphine are known to induce …

Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

S Montagud‐Romero… - European Journal of …, 2018 - Wiley Online Library
Social interaction is known to be the main source of stress in human beings, which explains
the translational importance of this research in animals. Evidence reported over the last …

Social stress during adolescence activates long-term microglia inflammation insult in reward processing nuclei

M Rodríguez-Arias, S Montagud-Romero… - PLoS …, 2018 - journals.plos.org
The experience of social stress during adolescence is associated with higher vulnerability to
drug use. Increases in the acquisition of cocaine self-administration, in the escalation of …