Ion channels and channelopathies in glomeruli

A Staruschenko, R Ma, O Palygin… - Physiological …, 2023 - journals.physiology.org
An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

The β Subunit of Voltage-Gated Ca2+ Channels

Z Buraei, J Yang - Physiological reviews, 2010 - journals.physiology.org
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

BK channels in the central nervous system

C Contet, SP Goulding, DA Kuljis, AL Barth - International review of …, 2016 - Elsevier
Large conductance Ca 2+-and voltage-activated K+(BK) channels are widely distributed in
the postnatal central nervous system (CNS). BK channels play a pleiotropic role in …

[HTML][HTML] Structure and function of the β subunit of voltage-gated Ca2+ channels

Z Buraei, J Yang - Biochimica Et Biophysica Acta (BBA)-Biomembranes, 2013 - Elsevier
The voltage-gated Ca2+ channel β subunit (Cavβ) is a cytosolic auxiliary subunit that plays
an essential role in regulating the surface expression and gating properties of high-voltage …

TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology

SE Dryer, J Reiser - American Journal of Physiology-Renal …, 2010 - journals.physiology.org
Loss or dysfunction of podocytes is a major cause of glomerular kidney disease. Several
genetic forms of glomerular disease are caused by mutations in genes that encode structural …

Voltage‐gated calcium channel nanodomains: molecular composition and function

MA Gandini, GW Zamponi - The FEBS journal, 2022 - Wiley Online Library
Voltage‐gated calcium (CaV) channels and their regulation by proteins at the synaptic cleft
play a critical role in neurotransmission. These interactions fine‐tune the synaptic response …

MaxiK channel and cell signalling

L Toro, M Li, Z Zhang, H Singh, Y Wu… - Pflügers Archiv-European …, 2014 - Springer
Abstract The large-conductance Ca 2+-and voltage-activated K+(MaxiK, BK, BK Ca, Slo1, K
Ca 1.1) channel role in cell signalling is becoming apparent as we learn how the channel …

[HTML][HTML] Differential expression of BK channel isoforms and β-subunits in rat neuro-vascular tissues

AN Poulsen, H Wulf, A Hay-Schmidt… - … et Biophysica Acta (BBA …, 2009 - Elsevier
We investigated the expression of splice variants and β-subunits of the BK channel (big
conductance Ca2+-activated K+ channel, Slo1, MaxiK, KCa1. 1) in rat cerebral blood …

Regulation of high‐voltage‐activated Ca2+ channel function, trafficking, and membrane stability by auxiliary subunits

R Felix, A Calderón‐Rivera… - … Membrane Transport and …, 2013 - Wiley Online Library
Voltage‐gated Ca2+ (CaV) channels mediate Ca2+ ions influx into cells in response to
depolarization of the plasma membrane. They are responsible for initiation of excitation …

Regulation of podocyte BKCa channels by synaptopodin, Rho, and actin microfilaments

EY Kim, JM Suh, YH Chiu… - American Journal of …, 2010 - journals.physiology.org
Mechanosensitive large-conductance Ca2+-activated K+ channels encoded by the Slo1
gene (BKCa channels) are expressed in podocytes. Here we show that BKCa channels …