Ochratoxin A: 50 years of research

F Malir, V Ostry, A Pfohl-Leszkowicz, J Malir, J Toman - Toxins, 2016 - mdpi.com
Since ochratoxin A (OTA) was discovered, it has been ubiquitous as a natural contaminant
of moldy food and feed. The multiple toxic effects of OTA are a real threat for human beings …

Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001–2018

BA Al-Jaal, M Jaganjac, A Barcaru… - Food and chemical …, 2019 - Elsevier
Human exposure to mycotoxins occurs mostly through dietary intake, although exposure
through dermal and inhalation routes has also been shown. Depending on the type of …

Farnesoid X receptor plays a key role in ochratoxin a-induced nephrotoxicity by targeting ferroptosis in vivo and in vitro

J Tang, J Zeng, L Chen, M Wang, S He… - Journal of Agricultural …, 2023 - ACS Publications
The mycotoxin ochratoxin A (OTA) causes nephrotoxicity, hepatotoxicity, and immunotoxicity
in animals and humans. The farnesoid X receptor (FXR) is a member of the NR family and is …

Human ochratoxin A biomarkers—From exposure to effect

SC Duarte, A Pena, CM Lino - Critical reviews in toxicology, 2011 - Taylor & Francis
Ochratoxin A (OTA) is a nephrotoxic mycotoxin that has received particular attention
because of the toxic effects, widespread occurrence in contaminated food and feed chain …

Mycotoxins in blood and urine of Swedish adolescents—Possible associations to food intake and other background characteristics

E Warensjö Lemming, A Montano Montes, J Schmidt… - Mycotoxin …, 2020 - Springer
The exposure to mycotoxins of Swedish adolescents is currently unknown. The aim of the
present study was to investigate the exposure to mycotoxins and their association with food …

Protective effect of lycopene against ochratoxin A induced renal oxidative stress and apoptosis in rats

SS Palabiyik, P Erkekoglu, ND Zeybek… - Experimental and …, 2013 - Elsevier
This study was designed to investigate the possible protective effect of lycopene against the
renal toxic effects of OTA. Male Sprague-Dawley rats (< 200 g, n= 6) were treated with OTA …

Ferroptosis is involved in quercetin-mediated alleviation of Ochratoxin A-induced kidney damage

Y Zhou, W Lu, K Huang, F Gan - Food and Chemical Toxicology, 2024 - Elsevier
Ochratoxin A (OTA) induces kidney damage in animals and humans. Ferroptosis is an iron-
dependent form of regulated cell death that is involved in OTA-induced kidney injury …

Simply amplified electrochemical aptasensor of ochratoxin A based on exonuclease-catalyzed target recycling

P Tong, L Zhang, JJ Xu, HY Chen - Biosensors and Bioelectronics, 2011 - Elsevier
A new “signal-on” aptasensor for ultrasensitive detection of Ochratoxin A (OTA) in wheat
starch was developed based on exonuclease-catalyzed target recycling. To construct the …

Double-probe signal enhancing strategy for toxin aptasensing based on rolling circle amplification

P Tong, WW Zhao, L Zhang, JJ Xu, HY Chen - Biosensors and …, 2012 - Elsevier
On the basis of aptamer-based rolling circle amplification (RCA) and magnetic beads (MBs),
a highly sensitive electrochemical method was developed for the determination of …

Ochratoxin A induces nephrotoxicity and immunotoxicity through different MAPK signaling pathways in PK15 cells and porcine primary splenocytes

F Gan, Y Zhou, L Hou, G Qian, X Chen, K Huang - Chemosphere, 2017 - Elsevier
Ochratoxin A (OTA) is reported to be a potent nephrotoxin and immunotoxin in animals and
humans. However, the mechanisms underlying OTA toxicity have not been clearly …