The human brain consumes 20% of the total basal oxygen (O 2) budget to support ATP
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …

Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …

Protease biology is intimately linked to the functional consequences of substrate cleavage
events. Human caspases are a family of 12 fate-determining cysteine proteases that are best …

Programmed cell death (PCD) plays a fundamental role in animal development and tissue
homeostasis. Abnormal regulation of this process is associated with a wide variety of human …

Microglia are the resident brain macrophages and they have been traditionally studied as
orchestrators of the brain inflammatory response during infections and disease. In addition …

The microtubule-associated protein tau is involved in a number of neurodegenerative
disorders, including Alzheimer's disease. Previous studies have linked oxidative stress and …

Naturally occurring axonal pruning and neuronal cell death help to sculpt neuronal
connections during development, but their mechanistic basis remains poorly understood …

The assembly of functional neural circuits requires the combined action of progressive and
regressive events. Regressive events encompass a variety of inhibitory developmental …

NMDA receptor-dependent synaptic modifications, such as long-term potentiation (LTP) and
long-term depression (LTD), are essential for brain development and function. LTD occurs …

Caspases are a family of cysteinyl aspartate-specific proteases that are highly conserved in
multicellular organisms and function as central regulators of apoptosis. A member of this …