Multiple mechanisms mediate thrombin generation and consequently the thrombin
concentration present during fibrin formation. First, the levels of pro-and anticoagulants …

New evidence has stirred up a long‐standing but undeservedly forgotten interest in the role
of erythrocytes, or red blood cells (RBCs), in blood clotting and its disorders. This review …

The nongenomic actions of thyroid hormone begin at receptors in the plasma membrane,
mitochondria or cytoplasm. These receptors can share structural homologies with nuclear …

Human red blood cells (RBC) are highly differentiated cells that have lost all organelles and
most intracellular machineries during their maturation process. RBC are fundamental for the …

Contraction of blood clots is necessary for hemostasis and wound healing and to restore
flow past obstructive thrombi, but little is known about the structure of contracted clots or the …

Fibrinolysis appears in many diverse physiological situations, and the components of the
system are well established, along with mechanistic details for the individual reactions and …

In contrast to an obsolete notion that erythrocytes, or red blood cells (RBC s), play a passive
and minor role in haemostasis and thrombosis, over the past decades there has been …

Platelet-driven blood clot contraction (retraction) is thought to promote wound closure and
secure hemostasis while preventing vascular occlusion. Notwithstanding its importance, clot …

Mid-life stage adults are at higher risk of developing venous thrombosis
(VT)/thromboembolism (VT/E). Aging is characterized by an overproduction of reactive …

Abstract Factor XIII (a)[FXIII (a)] stabilizes clots and increases resistance to fibrinolysis and
mechanical disruption. FXIIIa also mediates red blood cell (RBC) retention in contracting …