Genetic and biological hallmarks of colorectal cancer
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …
tumors, and these insights have illuminated early detection, risk stratification, prevention …
Targeting apoptosis in cancer therapy
BA Carneiro, WS El-Deiry - Nature reviews Clinical oncology, 2020 - nature.com
For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
Abstract Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …
RAF-MEK-ERK pathway in cancer evolution and treatment
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
Targeting apoptosis in cancer
P Singh, B Lim - Current oncology reports, 2022 - Springer
Abstract Purpose of Review Apoptosis is a major mechanism of cancer cell death. Thus,
evasion of apoptosis results in therapy resistance. Here, we review apoptosis modulators in …
evasion of apoptosis results in therapy resistance. Here, we review apoptosis modulators in …
Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy
JL Carter, K Hege, J Yang, HA Kalpage, Y Su… - Signal transduction and …, 2020 - nature.com
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …
second most common form of acute leukemia in children. Despite this, very little …
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
S Von Karstedt, A Montinaro, H Walczak - Nature Reviews Cancer, 2017 - nature.com
The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …
Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality
J Ishizawa, SF Zarabi, RE Davis, O Halgas, T Nii… - Cancer cell, 2019 - cell.com
The mitochondrial caseinolytic protease P (ClpP) plays a central role in mitochondrial
protein quality control by degrading misfolded proteins. Using genetic and chemical …
protein quality control by degrading misfolded proteins. Using genetic and chemical …
A Bayesian machine learning approach for drug target identification using diverse data types
NS Madhukar, PK Khade, L Huang, K Gayvert… - Nature …, 2019 - nature.com
Drug target identification is a crucial step in development, yet is also among the most
complex. To address this, we develop BANDIT, a Bayesian machine-learning approach that …
complex. To address this, we develop BANDIT, a Bayesian machine-learning approach that …
[HTML][HTML] ONC201 and imipridones: Anti-cancer compounds with clinical efficacy
ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-
inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G …
inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G …