Metformin, a biological and synthetic overview

ED Hernández-Velázquez, C Alba-Betancourt… - Bioorganic & Medicinal …, 2023 - Elsevier
Metformin is the most widely known anti-hyperglycemic, officially acquired by the USA
government in 1995 and in 2001 it became the most prescribed treatment for type II …

1, 3‐Oxazine as a promising scaffold for the development of biologically active lead molecules

N Gupta, V Saini, SM Basavarajaiah, MO Dar… - …, 2023 - Wiley Online Library
Heterocyclic compounds form an important part of wide range of biologically active
molecules. The heteroatom provides them specificity for various receptors. 1, 3‐oxazine has …

Iodine (III)‐Mediated Free‐Aniline Iodination through Acetyl Hypoiodite Formation: Study of the Reaction Pathway

N Mali, JG Ibarra‐Gutiérrez… - European Journal of …, 2022 - Wiley Online Library
The first iodine (III)‐mediated para‐selective iodination protocol for free anilines as well as
the mechanistic elucidation of the reaction pathway is described. The developed method …

Iodine (III) reagents for the aromatic functionalization with inorganic groups

MP Barrera-Nava, LA Segura-Quezada… - Tetrahedron, 2024 - Elsevier
Iodine (III) reagents have gained importance in organic synthesis due to their strong
oxidative properties in addition to several advantages over other related such as, non-toxic …

Differential Effect of 4H-Benzo[d] [1,3]oxazines on the Proliferation of Breast Cancer Cell Lines

I Fraire-Soto, JG Araujo-Huitrado… - Current Medicinal …, 2024 - benthamdirect.com
Background A family of 4 H-benzo [d][1, 3] oxazines were obtained from a group of N-(2-
alkynyl) aryl benzamides precursors via gold (I) catalysed chemoselective 6-exo-dig CO …

Gold (I)-Catalyzed Synthesis of 2, 2′-Biindoles via One-Pot Double Cycloisomerization Strategy

JG Ibarra-Gutiérrez, CR Solorio-Alvarado… - The Journal of …, 2024 - ACS Publications
The first systematic, concise and target-directed gold (I)-catalyzed synthesis of a family of 2,
2′-biindoles containing different substitution patterns is described. The developed protocol …

Catalyst-Free Synthesis of Functionalized 4-Substituted-4H-Benzo[d][1,3]oxazines via Intramolecular Cyclization of ortho-Amide-N-tosylhydrazones

J Yan, C Tran, P Retailleau, M Alami… - The Journal of Organic …, 2023 - ACS Publications
Functionalized 4-aryl-4 H-benzo [d][1, 3] oxazines are synthesized under transition-metal-
free conditions using ortho-amide-N-tosylhydrazones. This synthetic method uses readily …

Indomethacin Synthesis, Historical Overview of Their Structural Modifications

KR Torres‐Carbajal, LA Segura‐Quezada… - …, 2022 - Wiley Online Library
One of the most important (NSAID) non‐steroidal anti‐inflammatory drug‐containing the
indol core is represented by the indomethacin. This highly relevant compound has been …

1, 3-Naphthoxazine derivatives: Synthesis, in silico pharmacokinetic studies, antioxidant and photoprotective properties

E Pelit, AG Erturk, M Gul - Bioorganic Chemistry, 2024 - Elsevier
Investigation into the interactions between photoprotective agents and skin can offer a
precise understanding of their biological behaviors in vitro and in vivo, providing crucial …

Synthesis of 1, 3-oxazines based on piperazine

FR Louka, LG Ortte, MR Maier, NMH Salem… - Journal of Molecular …, 2025 - Elsevier
The oxazines bearing piperazinyl moieties namely 2-(tert-butyl)-6-((4-(2-(8-(tert-butyl)-6-
methyl-2H-benzo [e][1, 3] oxazin-3 (4H)-yl) ethyl) piperazin-1-yl) methyl)-4-methylphenol (1) …