Metformin, a biological and synthetic overview
ED Hernández-Velázquez, C Alba-Betancourt… - Bioorganic & Medicinal …, 2023 - Elsevier
Metformin is the most widely known anti-hyperglycemic, officially acquired by the USA
government in 1995 and in 2001 it became the most prescribed treatment for type II …
government in 1995 and in 2001 it became the most prescribed treatment for type II …
1, 3‐Oxazine as a promising scaffold for the development of biologically active lead molecules
Heterocyclic compounds form an important part of wide range of biologically active
molecules. The heteroatom provides them specificity for various receptors. 1, 3‐oxazine has …
molecules. The heteroatom provides them specificity for various receptors. 1, 3‐oxazine has …
Iodine (III)‐Mediated Free‐Aniline Iodination through Acetyl Hypoiodite Formation: Study of the Reaction Pathway
N Mali, JG Ibarra‐Gutiérrez… - European Journal of …, 2022 - Wiley Online Library
The first iodine (III)‐mediated para‐selective iodination protocol for free anilines as well as
the mechanistic elucidation of the reaction pathway is described. The developed method …
the mechanistic elucidation of the reaction pathway is described. The developed method …
Iodine (III) reagents for the aromatic functionalization with inorganic groups
MP Barrera-Nava, LA Segura-Quezada… - Tetrahedron, 2024 - Elsevier
Iodine (III) reagents have gained importance in organic synthesis due to their strong
oxidative properties in addition to several advantages over other related such as, non-toxic …
oxidative properties in addition to several advantages over other related such as, non-toxic …
Differential Effect of 4H-Benzo[d] [1,3]oxazines on the Proliferation of Breast Cancer Cell Lines
I Fraire-Soto, JG Araujo-Huitrado… - Current Medicinal …, 2024 - benthamdirect.com
Background A family of 4 H-benzo [d][1, 3] oxazines were obtained from a group of N-(2-
alkynyl) aryl benzamides precursors via gold (I) catalysed chemoselective 6-exo-dig CO …
alkynyl) aryl benzamides precursors via gold (I) catalysed chemoselective 6-exo-dig CO …
Gold (I)-Catalyzed Synthesis of 2, 2′-Biindoles via One-Pot Double Cycloisomerization Strategy
JG Ibarra-Gutiérrez, CR Solorio-Alvarado… - The Journal of …, 2024 - ACS Publications
The first systematic, concise and target-directed gold (I)-catalyzed synthesis of a family of 2,
2′-biindoles containing different substitution patterns is described. The developed protocol …
2′-biindoles containing different substitution patterns is described. The developed protocol …
Catalyst-Free Synthesis of Functionalized 4-Substituted-4H-Benzo[d][1,3]oxazines via Intramolecular Cyclization of ortho-Amide-N-tosylhydrazones
J Yan, C Tran, P Retailleau, M Alami… - The Journal of Organic …, 2023 - ACS Publications
Functionalized 4-aryl-4 H-benzo [d][1, 3] oxazines are synthesized under transition-metal-
free conditions using ortho-amide-N-tosylhydrazones. This synthetic method uses readily …
free conditions using ortho-amide-N-tosylhydrazones. This synthetic method uses readily …
Indomethacin Synthesis, Historical Overview of Their Structural Modifications
KR Torres‐Carbajal, LA Segura‐Quezada… - …, 2022 - Wiley Online Library
One of the most important (NSAID) non‐steroidal anti‐inflammatory drug‐containing the
indol core is represented by the indomethacin. This highly relevant compound has been …
indol core is represented by the indomethacin. This highly relevant compound has been …
1, 3-Naphthoxazine derivatives: Synthesis, in silico pharmacokinetic studies, antioxidant and photoprotective properties
Investigation into the interactions between photoprotective agents and skin can offer a
precise understanding of their biological behaviors in vitro and in vivo, providing crucial …
precise understanding of their biological behaviors in vitro and in vivo, providing crucial …
Synthesis of 1, 3-oxazines based on piperazine
FR Louka, LG Ortte, MR Maier, NMH Salem… - Journal of Molecular …, 2025 - Elsevier
The oxazines bearing piperazinyl moieties namely 2-(tert-butyl)-6-((4-(2-(8-(tert-butyl)-6-
methyl-2H-benzo [e][1, 3] oxazin-3 (4H)-yl) ethyl) piperazin-1-yl) methyl)-4-methylphenol (1) …
methyl-2H-benzo [e][1, 3] oxazin-3 (4H)-yl) ethyl) piperazin-1-yl) methyl)-4-methylphenol (1) …