JAK/STAT signaling and cervical cancer: from the cell surface to the nucleus

A Valle-Mendiola, A Gutiérrez-Hoya, I Soto-Cruz - Genes, 2023 - mdpi.com
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway constitutes a rapid signaling module from the cell surface to the nucleus, and …

Cervical microbiome and cytokine profile at various stages of cervical cancer: a pilot study

A Audirac-Chalifour, K Torres-Poveda… - PloS one, 2016 - journals.plos.org
Cervical cancer (CC) is caused by high-risk human papillomavirus persistence due to the
immunosuppressive tumor microenvironment mediated by cytokines. Vaginal microbiota …

Cervical Cancer Induction Enhancement Potential of Chlamydia Trachomatis: A Systematic Review

S Karim, T Souho, M Benlemlih, B Bennani - Current microbiology, 2018 - Springer
Human papillomavirus (HPV) persistent infection is the necessary but not sufficient cause of
cervical cancer. Other co-factors are required to induce cell transformation that will evolve to …

Characterization of cervico-vaginal microbiota in women developing persistent high-risk Human Papillomavirus infection

M Di Paola, C Sani, AM Clemente, A Iossa, E Perissi… - Scientific reports, 2017 - nature.com
Abstract Changes in cervico-vaginal microbiota with Lactobacillus depletion and increased
microbial diversity facilitate human papillomavirus (HPV) infection and might be involved in …

Depiction of vaginal microbiota in women with high-risk human papillomavirus infection

ZT Wei, HL Chen, CF Wang, GL Yang… - Frontiers in Public …, 2021 - frontiersin.org
Persistent infection with the carcinogenic human papillomavirus (HPV) is a prerequisite for
the progression of cervical lesions and cancer. A growing body of research has focused on …

Relationship between the cervical microbiome, HIV status, and precancerous lesions

C Klein, D Gonzalez, K Samwel, C Kahesa… - MBio, 2019 - Am Soc Microbiol
Nearly all cervical cancers are causally associated with human papillomavirus (HPV). The
burden of HPV-associated dysplasias in sub-Saharan Africa is influenced by HIV. To …

Dysbiosis of vaginal microbiota associated with persistent high-risk human papilloma virus infection

L Mei, T Wang, Y Chen, D Wei, Y Zhang, T Cui… - Journal of translational …, 2022 - Springer
Background The status of vaginal microbiota in persistent high-risk human papilloma virus
(HR-HPV) infection is unclear. The present work aimed to identify the vaginal microbiota of …

How the cervical microbiota contributes to cervical cancer risk in sub-Saharan Africa

C Klein, C Kahesa, J Mwaiselage, JT West… - Frontiers in Cellular …, 2020 - frontiersin.org
Despite ongoing efforts, sub-Saharan Africa faces a higher cervical cancer burden than
anywhere else in the world. Besides HPV infection, definitive factors of cervical cancer are …

Vaginal microbiota and cytokine microenvironment in HPV clearance/persistence in women surgically treated for cervical intraepithelial neoplasia: an observational …

E Caselli, M D'Accolti, E Santi, I Soffritti… - Frontiers in Cellular …, 2020 - frontiersin.org
High-risk human papillomaviruses (hrHPVs) are causally related to cervical intraepithelial
neoplasia (CIN) and subsequent cervical cancer (CC). The vaginal microbiome has been …

Detection of sexually transmitted pathogens and co-infection with human papillomavirus in women residing in rural Eastern Cape, South Africa

O Taku, A Brink, TL Meiring, K Phohlo, CB Businge… - PeerJ, 2021 - peerj.com
Background South African women of reproductive age have a high burden of sexually
transmitted infections (STIs), including human papillomavirus (HPV) infection. However …