Animal models of Alzheimer's disease and frontotemporal dementia
Insoluble protein aggregates have been linked to Alzheimer's disease (AD) and
frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of …
frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of …
Human body fluid proteome analysis
The focus of this article is to review the recent advances in proteome analysis of human
body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar …
body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar …
Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β
N Schonrock, DT Humphreys, T Preiss… - Journal of Molecular …, 2012 - Springer
MicroRNAs (miRNAs) are small non-coding RNA regulators of protein synthesis that are
essential for normal brain development and function. Their profiles are significantly altered …
essential for normal brain development and function. Their profiles are significantly altered …
[HTML][HTML] March separate, strike together—Role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease
The energy demand and calcium buffering requirements of the brain are met by the high
number of mitochondria in neurons and in these, especially at the synapses. Mitochondria …
number of mitochondria in neurons and in these, especially at the synapses. Mitochondria …
Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunction
YA Lim, V Rhein, G Baysang, F Meier, A Poljak… - …, 2010 - Wiley Online Library
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are leading causes of
morbidity and mortality in the elderly. Both diseases are characterized by amyloid deposition …
morbidity and mortality in the elderly. Both diseases are characterized by amyloid deposition …
Oligomeric and fibrillar species of β-amyloid (Aβ42) both impair mitochondrial function in P301L tau transgenic mice
A Eckert, S Hauptmann, I Scherping… - Journal of molecular …, 2008 - Springer
We recently provided evidence for a mitochondrial dysfunction in P301L tau transgenic
mice, a strain modeling the tau pathology of Alzheimer's disease (AD) and frontotemporal …
mice, a strain modeling the tau pathology of Alzheimer's disease (AD) and frontotemporal …
MicroRNA networks surrounding APP and amyloid-β metabolism—implications for Alzheimer's disease
MicroRNAs (miRNAs) are small non-coding RNA regulators of protein synthesis that function
as “fine-tuning” tools of gene expression in development and tissue homeostasis. Their …
as “fine-tuning” tools of gene expression in development and tissue homeostasis. Their …
Modes of Aβ toxicity in Alzheimer's disease
Alzheimer's disease (AD) is reaching epidemic proportions, yet a cure is not yet available.
While the genetic causes of the rare familial inherited forms of AD are understood, the …
While the genetic causes of the rare familial inherited forms of AD are understood, the …
[HTML][HTML] Animal models reveal role for tau phosphorylation in human disease
J Götz, A Gladbach, L Pennanen, J van Eersel… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Many proteins that are implicated in human disease are posttranslationally modified. This
includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated …
includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated …
Data merging for integrated microarray and proteomic analysis
The functioning of even a simple biological system is much more complicated than the sum
of its genes, proteins and metabolites. A premise of systems biology is that molecular …
of its genes, proteins and metabolites. A premise of systems biology is that molecular …