Non‐alcoholic fatty liver disease (NAFLD) is not a single disease entity, rather it describes a
spectrum of liver conditions that range from fatty liver (steatosis) to more severe steatosis …

There are many forms of iron storage disease, some hereditary and some acquired. The
most common of the hereditary forms is HFE-associated hemochromatosis, and it is this …

BACKGROUND Doxorubicin is associated with progressive cardiac dysfunction, possibly
through the formation of doxorubicin‐iron complexes leading to free‐radical injury. The …

Background: Complete deletion of the complete AZFc interval of the Y chromosome is the
most common known genetic cause of human male infertility. Two partial AZFc deletions …

Most cases of genetic hemochromatosis (GH) are associated with the HFE C282Y/C282Y (p.
Cys282Tyr/p. Cys282Tyr) genotype in white populations. The symptoms expressed by …

Background The pivotal role of mitochondria in energy production and free radical
generation suggests that the mitochondrial genome could have an important influence on …

The A16V mitochondrial targeting sequence polymorphism influences the antioxidant
activity of MnSOD, an enzyme involved in neutralising iron induced oxidative stress. Patients …

Since its original description as a rare disease of iron overload resulting in liver disease,
diabetes mellitus, and bronzing of the skin ('bronze diabetes'), hereditary hemochromatosis …

The molecular basis of haemochromatosis has proved more complex than expected. After
the 1996 identification of the main causative gene HFE and confirmation that most patients …

Background & Aims Hereditary hemochromatosis (HH) is the most common form of genetic
iron loading disease. It is mainly related to the homozygous C282Y/C282Y mutation in the …