A complex interplay between Akt, TSC2 and the two mTOR complexes
J Huang, BD Manning - Biochemical Society Transactions, 2009 - portlandpress.com
Akt/PKB (protein kinase B) both regulates and is regulated by the TSC (tuberous sclerosis
complex) 1–TSC2 complex. Downstream of PI3K (phosphoinositide 3-kinase), Akt …
complex) 1–TSC2 complex. Downstream of PI3K (phosphoinositide 3-kinase), Akt …
Regulation of Carbohydrate Energy Metabolism in Drosophila melanogaster
J Mattila, V Hietakangas - Genetics, 2017 - academic.oup.com
Carbohydrate metabolism is essential for cellular energy balance as well as for the
biosynthesis of new cellular building blocks. As animal nutrient intake displays temporal …
biosynthesis of new cellular building blocks. As animal nutrient intake displays temporal …
Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
E Owusu-Ansah, U Banerjee - Nature, 2009 - nature.com
Reactive oxygen species (ROS), produced during various electron transfer reactions in vivo,
are generally considered to be deleterious to cells. In the mammalian haematopoietic …
are generally considered to be deleterious to cells. In the mammalian haematopoietic …
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
Sestrins are conserved proteins that accumulate in cells exposed to stress, potentiate
adenosine monophosphate–activated protein kinase (AMPK), and inhibit activation of target …
adenosine monophosphate–activated protein kinase (AMPK), and inhibit activation of target …
Skeletal muscle tissue engineering: methods to form skeletal myotubes and their applications
Skeletal muscle tissue engineering (SMTE) aims to repair or regenerate defective skeletal
muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two …
muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two …
Molecular mechanisms of metabolic regulation by insulin in Drosophila
AA Teleman - Biochemical Journal, 2010 - portlandpress.com
The insulin signalling pathway is highly conserved from mammals to Drosophila. Insulin
signalling in the fly, as in mammals, regulates a number of physiological functions, including …
signalling in the fly, as in mammals, regulates a number of physiological functions, including …
[HTML][HTML] The L-cell in nutritional sensing and the regulation of appetite
E Spreckley, KG Murphy - Frontiers in nutrition, 2015 - frontiersin.org
The gastrointestinal (GI) tract senses the ingestion of food and responds by signaling to the
brain to promote satiation and satiety. Representing an important part of the gut–brain axis …
brain to promote satiation and satiety. Representing an important part of the gut–brain axis …
Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle
Low endogenous testosterone production, known as hypogonadism is commonly
associated with conditions inducing muscle wasting. Akt signaling can control skeletal …
associated with conditions inducing muscle wasting. Akt signaling can control skeletal …
Regulation of tissue growth through nutrient sensing
V Hietakangas, SM Cohen - Annual review of genetics, 2009 - annualreviews.org
Nutrition is a key regulator of tissue growth. In animals, nutritional status is monitored and
signaled at both the cellular and systemic levels. The main mediator of cellular nutrient …
signaled at both the cellular and systemic levels. The main mediator of cellular nutrient …
Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease
JA Carson, SC Manolagas - Bone, 2015 - Elsevier
Estrogens and androgens influence the growth and maintenance of bones and muscles and
are responsible for their sexual dimorphism. A decline in their circulating levels leads to loss …
are responsible for their sexual dimorphism. A decline in their circulating levels leads to loss …