Nervous system function and plasticity rely on the complex architecture of neuronal networks
elaborated during development, when neurons acquire their specific and complex shape …

Cytoskeleton-associated protein-glycine-rich (CAP-Gly) domains are protein-interaction
modules implicated in important cellular processes and in hereditary human diseases. A …

Tubulin folding cofactors (TFCs) are required for tubulin folding, α/β tubulin heterodimer
formation, and microtubule (MT) dynamics in yeast and mammals. However, the functions of …

Amyotrophic lateral sclerosis (ALS) is an aggressive multifactorial disease converging on a
common pathology: the degeneration of motor neurons (MNs), their axons and …

Successful axonal outgrowth in the adult central nervous system (CNS) is central to the
process of nerve regeneration and brain repair. To date, much of the knowledge on axonal …

Genetic and functional studies suggest diverse pathways being affected in the
neurodegenerative disease amyotrophic lateral sclerosis (ALS), while knowledge about …

Microcystin-LR (MCLR) is a commonly encountered blue-green algal hepatotoxin and a
known inhibitor of cellular protein phosphatase (PP), however, little is known about its …

Colchicine has been used to treat gout and, more recently, to effectively prevent
autoinflammatory diseases and both primary and recurrent episodes of pericarditis. The anti …

Plexins are a family of single-pass transmembrane proteins that serve as cell surface
receptors for Semaphorins during the embryonic development of animals. Semaphorin …

Tubulin, the most abundant axonemal protein, is extensively modified by several highly
conserved post-translational mechanisms including acetylation, detyrosination …