Virus infections usually begin in peripheral tissues and can invade the mammalian nervous
system (NS), spreading into the peripheral (PNS) and more rarely the central (CNS) nervous …

Neurotrophins have long been known to promote the survival and differentiation of
vertebrate neurons. However, these growth factors can also induce cell death through the …

The full scale of the global burden of human rabies is unknown, owing to inadequate
surveillance of this fatal disease. However, the terror of hydrophobia, a cardinal symptom of …

There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine
receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin …

The neurotrophins, a class of four related growth factors, utilize a dual receptor system
consisting of Trk receptor tyrosine kinases and the structurally unrelated p75 NTR to …

To reach the central nervous system (CNS), pathogens have to circumvent the wall of tightly
sealed endothelial cells that compose the blood–brain barrier. Neuronal projections that …

Rabies virus (RABV) is a neurotropic virus that depends on long distance axonal transport in
order to reach the central nervous system (CNS). The strategy RABV uses to hijack the …

Targeted delivery of nucleic acids into disease sites of human body has been attempted for
decades, but both viral and non-viral vectors are yet to meet our expectations. Safety …

Rabies viral encephalitis, though one of the oldest recognized infectious disease of humans,
remains an incurable, fatal encephalomyelitis, despite advances in understanding of its …

Neurotrophins (NTs) are members of a neuronal growth factor protein family whose action is
mediated by the tropomyosin receptor kinase (TRK) receptor family receptors and the p75 …