The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer.
Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has …

Prostate organogenesis is a complex process that is primarily mediated by the presence of
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …

Estrogen receptor and its ligand, estradiol, have long been thought to be essential for
survival, fertility, and female sexual differentiation and development. Consistent with this …

The androgen receptor (AR) plays a key role in progression to incurable androgen ablation–
resistant prostate cancer (PCA). We have identified three novel AR splice variants lacking …

I. Introduction IN 1953 lohn Morris, an obstetrician at Yale University, reported a series of 82
individuals (80 cases collated from the literature and two cases of his own) who had a …

Background Metastatic prostate cancer is a leading cause of cancer-related death in men.
The rate of response to androgen ablation is high, but most patients relapse as a result of …

Androgen receptor (AR) is a member of the steroid hormone receptor family of molecules.
AR primarily is responsible for mediating the physiologic effects of androgens by binding to …

Alternative splicing is an important mechanism for increasing functional diversity from a
limited set of genes. Deregulation of this process is common in diverse pathologic …

INCaP prostate tumor cells contain an abnormal androgen receptor system. Progestagens,
estradiol and anti-androgens can compete with androgens for binding to the androgen …

It is paramount that any child or adolescent with a suspected disorder of sex development
(DSD) is assessed by an experienced clinician with adequate knowledge about the range of …