Androgen signaling in prostate cancer
The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer.
Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has …
Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has …
Prostate organogenesis: tissue induction, hormonal regulation and cell type specification
R Toivanen, MM Shen - Development, 2017 - journals.biologists.com
Prostate organogenesis is a complex process that is primarily mediated by the presence of
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
DB Lubahn, JS Moyer, TS Golding… - Proceedings of the …, 1993 - National Acad Sciences
Estrogen receptor and its ligand, estradiol, have long been thought to be essential for
survival, fertility, and female sexual differentiation and development. Consistent with this …
survival, fertility, and female sexual differentiation and development. Consistent with this …
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion–resistant growth
Z Guo, X Yang, F Sun, R Jiang, DE Linn, H Chen… - Cancer research, 2009 - AACR
The androgen receptor (AR) plays a key role in progression to incurable androgen ablation–
resistant prostate cancer (PCA). We have identified three novel AR splice variants lacking …
resistant prostate cancer (PCA). We have identified three novel AR splice variants lacking …
Androgen receptor defects: historical, clinical, and molecular perspectives
CA Quigley, A De Bellis, KB Marschke… - Endocrine …, 1995 - academic.oup.com
I. Introduction IN 1953 lohn Morris, an obstetrician at Yale University, reported a series of 82
individuals (80 cases collated from the literature and two cases of his own) who had a …
individuals (80 cases collated from the literature and two cases of his own) who had a …
Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer
ME Taplin, GJ Bubley, TD Shuster… - … England Journal of …, 1995 - Mass Medical Soc
Background Metastatic prostate cancer is a leading cause of cancer-related death in men.
The rate of response to androgen ablation is high, but most patients relapse as a result of …
The rate of response to androgen ablation is high, but most patients relapse as a result of …
Molecular biology of the androgen receptor
EP Gelmann - Journal of clinical oncology, 2002 - ascopubs.org
Androgen receptor (AR) is a member of the steroid hormone receptor family of molecules.
AR primarily is responsible for mediating the physiologic effects of androgens by binding to …
AR primarily is responsible for mediating the physiologic effects of androgens by binding to …
[HTML][HTML] Alternatively spliced androgen receptor variants
SM Dehm, DJ Tindall - Endocrine-related cancer, 2011 - erc.bioscientifica.com
Alternative splicing is an important mechanism for increasing functional diversity from a
limited set of genes. Deregulation of this process is common in diverse pathologic …
limited set of genes. Deregulation of this process is common in diverse pathologic …
A mutation in the ligand binding domain of the androgen receptor of human INCaP cells affects steroid binding characteristics and response to anti-androgens
J Veldscholte, C Ris-Stalpers, G Kuiper… - Biochemical and …, 1990 - Elsevier
INCaP prostate tumor cells contain an abnormal androgen receptor system. Progestagens,
estradiol and anti-androgens can compete with androgens for binding to the androgen …
estradiol and anti-androgens can compete with androgens for binding to the androgen …
Society for Endocrinology UK guidance on the initial evaluation of an infant or an adolescent with a suspected disorder of sex development (Revised 2015)
It is paramount that any child or adolescent with a suspected disorder of sex development
(DSD) is assessed by an experienced clinician with adequate knowledge about the range of …
(DSD) is assessed by an experienced clinician with adequate knowledge about the range of …