Poststroke cognitive impairment and dementia (PSCID) is a major source of morbidity and
mortality after stroke worldwide. PSCID occurs as a consequence of ischemic stroke …

Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

UK Biobank is a population-based cohort of half a million participants aged 40–69 years
recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi …

The Japanese Society of Hypertension (JSH) revised the Guidelines for the Management of
Hypertension 2014 (JSH 2014), and published the JSH 2019. In the development of the JSH …

Vascular cognitive impairment (VCI) is predominately caused by vascular risk factors and
cerebrovascular disease. VCI includes a broad spectrum of cognitive disorders, from mild …

Importance Covert vascular brain injury (VBI) is highly prevalent in community-dwelling
older persons, but its clinical and therapeutic implications are debated. Objective To better …

Stroke is the second leading cause of death with substantial unmet therapeutic needs. To
identify potential stroke therapeutic targets, we estimate the causal effects of 308 plasma …

Medical imaging has enormous potential for early disease prediction, but is impeded by the
difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to …

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral …

Sleep disturbances and dementia are two common and significant health problems in older
adults. Investigations suggest that sleep disturbances might increase the risk of dementia …