Emerging roles of tRNA-derived fragments in cancer
M Fu, J Gu, M Wang, J Zhang, Y Chen, P Jiang, T Zhu… - Molecular cancer, 2023 - Springer
Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …
The life and times of a tRNA
EM Phizicky, AK Hopper - RNA, 2023 - rnajournal.cshlp.org
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …
and insights in the last several years. We now have unprecedented knowledge of each step …
tRNA-derived RNA fragments in cancer: current status and future perspectives
Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades,
and their fundamental roles in human diseases have been well established. Transfer RNAs …
and their fundamental roles in human diseases have been well established. Transfer RNAs …
LTR-retrotransposon control by tRNA-derived small RNAs
Transposon reactivation is an inherent danger in cells that lose epigenetic silencing during
developmental reprogramming. In the mouse, long terminal repeat (LTR)-retrotransposons …
developmental reprogramming. In the mouse, long terminal repeat (LTR)-retrotransposons …
Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets
Background tRFs, 14 to 32 nt long single-stranded RNA derived from mature or precursor
tRNAs, are a recently discovered class of small RNA that have been found to be present in …
tRNAs, are a recently discovered class of small RNA that have been found to be present in …
On the expanding roles of tRNA fragments in modulating cell behavior
R Magee, I Rigoutsos - Nucleic acids research, 2020 - academic.oup.com
The fragments that derive from transfer RNAs (tRNAs) are an emerging category of
regulatory RNAs. Known as tRFs, these fragments were reported for the first time only a …
regulatory RNAs. Known as tRFs, these fragments were reported for the first time only a …
Roles and regulation of tRNA-derived small RNAs in animals
S Muthukumar, CT Li, RJ Liu, C Bellodi - Nature Reviews Molecular Cell …, 2024 - nature.com
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
[HTML][HTML] tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus …
X Yu, Y Xie, S Zhang, X Song, B Xiao, Z Yan - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract tRNA-derived fragments (tRFs) are a new category of regulatory noncoding RNAs
with distinct biological functions in cancers and stress-induced diseases. Herein, we first …
with distinct biological functions in cancers and stress-induced diseases. Herein, we first …
tRNA-derived small RNA: a novel regulatory small non-coding RNA
S Li, Z Xu, J Sheng - Genes, 2018 - mdpi.com
Deep analysis of next-generation sequencing data unveils numerous small non-coding
RNAs with distinct functions. Recently, fragments derived from tRNA, named as tRNA …
RNAs with distinct functions. Recently, fragments derived from tRNA, named as tRNA …
Emerging roles of tRNA in adaptive translation, signalling dynamics and disease
S Kirchner, Z Ignatova - Nature Reviews Genetics, 2015 - nature.com
Abstract tRNAs, nexus molecules between mRNAs and proteins, have a central role in
translation. Recent discoveries have revealed unprecedented complexity of tRNA …
translation. Recent discoveries have revealed unprecedented complexity of tRNA …