Recent years have witnessed major advances that have improved outcome of adults with
acute lymphoblastic leukemia (ALL). The emergence of the concept of measurable residual …

Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a
leading cause of cancer death in the young. In the last decade, microarray and sequencing …

Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss
of CREBBP facilitates the development of germinal center (GC)–derived lymphomas in mice …

Background Although aberrant DNA methylation has been observed previously in acute
lymphoblastic leukemia (ALL), the patterns of differential methylation have not been …

Acute lymphoblastic leukaemia (ALL) is the commonest childhood cancer and an important
cause of morbidity from haematological malignancies in adults. In the past several years, we …

Genomic classification has improved risk assignment of pediatric, but not adult B-lineage
acute lymphoblastic leukemia (B-ALL). The international UKALLXII/ECOG-ACRIN E2993 (# …

CD25 is the alpha‐chain of the heterotrimer IL‐2 receptor. CD25 is expressed on the surface
of both immune and non‐immune cells with different frequencies. For cancers, CD25 is …

The methylcytosine dioxygenase TET1 ('ten-eleven translocation 1') is an important
regulator of 5-hydroxymethylcytosine (5hmC) in embryonic stem cells. The diminished …

Interferon-induced transmembrane protein 3 (IFITM3) has previously been identified as an
endosomal protein that blocks viral infection,–. Here we studied clinical cohorts of patients …

BCL6 was initially discovered as an oncogene in B-cell lymphomas, where it drives the
malignant phenotype by repressing proliferation and DNA damage checkpoints and …