One of the most important achievements of bacteria is its capability to adapt to the changing
conditions of the environment. The competition for nutrients with other microorganisms …

Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …

Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

Microbial production of antibiotics is common, but our understanding of their roles in the
environment is limited. In this study, we explore long-standing observations that microbes …

Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …

Actinomycetes are a rich source of natural products, and these mycelial bacteria produce the
majority of the known antibiotics. The increasing difficulty to find new drugs via high …

Engineering of regulatory mechanisms that control the biosynthesis of bioactive secondary
metabolites is an approach to increase the production of valuable fermentation products …

The transcription of amtB in Streptomyces coelicolor has been proposed to be counter-
regulated by GlnR (a global regulator for nitrogen metabolism) and PhoP (a global regulator …

The two‐component system AfsQ1/Q2 of S treptomyces coelicolor was identified in our
previous work as a pleiotropic regulator for antibiotic biosynthesis and morphological …

Bacteria of the Streptomyces genus constitute an authentic biotech gold mine thanks to their
ability to produce a myriad of compounds and enzymes of great interest at various clinical …