Chitin is one of the most abundant polysaccharide found on earth. The deacetylated form of
chitin viz. chitosan has been reported for its various important pharmacological properties …

The rational design and application of mRNA‐based medicine have recently yielded some
key successes in the clinical management of human diseases. mRNA technology allows for …

The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …

In non-viral gene therapy, cationic polymers and lipids are frequently used to encapsulate
macromolecular therapeutics into nanoparticles. During their journey to deliver the cargo to …

Abstract pH-responsive polymers contain ionic functional groups as pendants in their
structure. The total number of charged groups on polymer chains determines the overall …

Gene therapy is a promising strategy for treating challenging diseases. The successful
delivery of genes is a critical step for gene therapy. However, concerns about …

In gene therapy, endosomal escape represents a major bottleneck since nanoparticles often
remain entrapped inside endosomes and are trafficked toward the lysosomes for …

Immunotherapy is an emerging treatment option for use following traditional cancer
treatments (surgical resection, radiotherapy and chemotherapy). Due to the complexity of the …

Cationic polymers are promising antibacterial agents because bacteria have a low
propensity to develop resistance against them, but they usually have low biocompatibility …

Alternatives to efficient viral vectors in gene therapy are desired because of their poor safety
profiles. Chitosan is a promising non-viral nucleotide delivery vector because of its …