Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Intrinsically disordered regions (IDRs) are especially enriched among proteins that regulate
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …

The association between cancer and autoimmune disease is unexplained, exemplified by T
cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic …

Through a comprehensive review and in silico analysis of reported data on STAT‐linked
diseases, we analysed the communication pathways and interactome of the seven STATs in …

The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in
immune regulation and homeostasis and play a crucial role in the development and function …

Background The outcome of hepatocellular carcinoma (HCC) is limited by its complex
molecular characteristics and changeable tumor microenvironment (TME). Here we focused …

Molecular dynamics (MD) is a core methodology of molecular modeling and computational
design for the study of the dynamics and temporal evolution of molecular systems. MD …

Gastric cancer remains one of the most common deadly diseases and lacks effective
targeted therapies. In the present study, we confirmed that the signal transducer and …

Nowadays, molecular research is essential for the better understanding of tumor cells'
pathophysiology. The increasing number of neoplasms is taken under 'the molecular …

Simple Summary STAT3 and STAT5B mutations have been identified in a subset of T and
NK large granular lymphocytic leukemia (T/NK-LGLL). The aim of our study was to evaluate …