Type I and III interferon responses in SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19), the current pandemic disease, is caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Type I and III …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Type I and III …
ISG15 in antiviral immunity and beyond
YC Perng, DJ Lenschow - Nature Reviews Microbiology, 2018 - nature.com
The host response to viral infection includes the induction of type I interferons and the
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …
Interferons α and β in cancer: therapeutic opportunities from new insights
EC Borden - Nature Reviews Drug Discovery, 2019 - nature.com
Over the past decade, preclinical and clinical research have confirmed the essential role of
interferons for effective host immunological responses to malignant cells. Type I interferons …
interferons for effective host immunological responses to malignant cells. Type I interferons …
[HTML][HTML] All about the RNA: interferon-stimulated genes that interfere with viral RNA processes
E Yang, MMH Li - Frontiers in immunology, 2020 - frontiersin.org
Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …
Differential regulation of type I and type III interferon signaling
ML Stanifer, K Pervolaraki, S Boulant - International journal of molecular …, 2019 - mdpi.com
Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen
infections by controlling inflammation and immune response by directly inducing anti …
infections by controlling inflammation and immune response by directly inducing anti …
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …
Immune responses and immunopathology in acute and chronic viral hepatitis
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …
[PDF][PDF] Methyltransferase SETD2-mediated methylation of STAT1 is critical for interferon antiviral activity
K Chen, J Liu, S Liu, M Xia, X Zhang, D Han, Y Jiang… - Cell, 2017 - cell.com
Interferon-α (IFNα) signaling is essential for antiviral response via induction of IFN-
stimulated genes (ISGs). Through a non-biased high-throughput RNAi screening of 711 …
stimulated genes (ISGs). Through a non-biased high-throughput RNAi screening of 711 …
[PDF][PDF] Innate-like cytotoxic function of bystander-activated CD8+ T cells is associated with liver injury in acute hepatitis A
Acute hepatitis A (AHA) involves severe CD8+ T cell-mediated liver injury. Here we showed
during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus …
during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus …
Transcriptional regulation of antiviral interferon-stimulated genes
Interferon-stimulated genes (ISGs) are a group of gene products that coordinately combat
pathogen invasions, in particular viral infections. Transcription of ISGs occurs rapidly upon …
pathogen invasions, in particular viral infections. Transcription of ISGs occurs rapidly upon …