Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …

A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …

It is not known at present whether neuronal cell-type diversity—defined by cell-type-specific
anatomical, biophysical, functional and molecular signatures—can be reduced to relatively …

Abstract Background Several Cre reporter strains of mice have been described, in which a
lacZ gene is turned on in cells expressing Cre recombinase, as well as their daughter cells …

Neural circuits are assembled with remarkable precision during embryonic development,
and the selectivity inherent in their formation helps to define the behavioural repertoire of the …

Inductive signals and transcription factors involved in motor neuron generation have been
identified, raising the question of whether these developmental insights can be used to …

OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the
pMN domain of the spinal cord, which sequentially generates motoneurons and …

The enormous diversity of cell types that characterizes any animal nervous system is defined
by neuron-type-specific gene batteries that endow cells with distinct anatomical and …

The generation of neurons from stem cells involves the activity of proneural basic helix-loop-
helix (bHLH) proteins, but the mechanism by which these proteins irreversibly commit stem …

Distinct classes of motor neurons and ventral interneurons are generated by the graded
signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing …