Contemporary medical, device, and surgical therapies for obesity in adults

CM Perdomo, RV Cohen, P Sumithran, K Clément… - The Lancet, 2023 - thelancet.com
The goal of obesity management is to improve health. Sustained weight loss of more than
10% overall bodyweight improves many of the complications associated with obesity (eg …

Why does obesity cause diabetes?

S Klein, A Gastaldelli, H Yki-Järvinen, PE Scherer - Cell metabolism, 2022 - cell.com
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …

Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation

I Lingvay, P Sumithran, RV Cohen, CW le Roux - The Lancet, 2022 - thelancet.com
Obesity is now recognised as a disease that is associated with serious morbidity and
increased mortality. One of its main metabolic complications is type 2 diabetes, as the two …

Chronic kidney disease

K Kalantar-Zadeh, TH Jafar, D Nitsch, BL Neuen… - The lancet, 2021 - thelancet.com
Chronic kidney disease is a progressive disease with no cure and high morbidity and
mortality that occurs commonly in the general adult population, especially in people with …

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

V Perkovic, MJ Jardine, B Neal… - New England journal …, 2019 - Mass Medical Soc
Background Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but
few effective long-term treatments are available. In cardiovascular trials of inhibitors of …

Metabolic surgery versus conventional medical therapy in patients with type 2 diabetes: 10-year follow-up of an open-label, single-centre, randomised controlled trial

G Mingrone, S Panunzi, A De Gaetano, C Guidone… - The Lancet, 2021 - thelancet.com
Background No data from randomised controlled trials of metabolic surgery for diabetes are
available beyond 5 years of follow-up. We aimed to assess 10-year follow-up after surgery …

2022 American Society of Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) indications …

D Eisenberg, SA Shikora, E Aarts, A Aminian… - 2023 - Springer
Major updates to 1991 National Institutes of Health guidelines for bariatric surgery Metabolic
and bariatric surgery (MBS) is recommended for individuals with a body mass index (BMI)> …

GLP-1 agonist to treat obesity and prevent cardiovascular disease: what have we achieved so far?

MR Pedrosa, DR Franco, HW Gieremek… - Current atherosclerosis …, 2022 - Springer
Abstract Purpose of Review To discuss evidence supporting the use of glucagon-like
peptide 1 receptor agonists (GLP-1RA) to treat obesity and their role as a cardioprotective …

Development and validation of an interpretable machine learning-based calculator for predicting 5-year weight trajectories after bariatric surgery: a multinational …

P Saux, P Bauvin, V Raverdy, J Teigny… - The Lancet Digital …, 2023 - thelancet.com
Background Weight loss trajectories after bariatric surgery vary widely between individuals,
and predicting weight loss before the operation remains challenging. We aimed to develop a …

Bariatric surgery for the treatment of chronic kidney disease in obesity and type 2 diabetes mellitus

NG Docherty, CW le Roux - Nature Reviews Nephrology, 2020 - nature.com
Bariatric surgery is an effective therapy for obesity, hypertension and type 2 diabetes
mellitus that is refractory to maximal medical therapy. Results of long-term cohort studies …