ABCA7 loss-of-function variants are associated with increased risk of Alzheimer's disease
(AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we …

Introduction Spinal cord injury (SCI) affects 25,000–50,000 people around the world each
year and there is no cure for SCI patients currently. The primary injury damages spinal cord …

Spinal cord injury (SCI) is a serious central nervous system (CNS) injury disease related to
hypoxia-ischemia and inflammation. It is characterized by excessive reactive oxygen …

Mitochondrial dysfunction is linked to degenerative diseases, resulting from cardiolipin (CL)-
induced disruption of cristae structure in the inner mitochondrial membrane (IMM); therefore …

Cardiolipin is a unique phospholipid of the inner mitochondrial membrane (IMM) as well as
in bacteria. It performs several vital functions such as resisting osmotic rupture and …

Poly (ADP-ribose) polymerase (PARP) plays a key role in repairing DNA damage, and
several PARP inhibitors have been approved as treatments in BRCA1/2 mutated breast and …

Cardiolipin (CL) is a mitochondria-exclusive phospholipid synthesized in the inner
mitochondrial membrane. CL plays a key role in mitochondrial membranes, impacting a …

Schwann cell transplantation is considered one of the most promising cell-based therapy to
repair injured spinal cord due to its unique growth-promoting and myelin-forming properties …

Previous studies have reported upregulation of heme oxygenase-1 in different central
nervous system injury models. Heme oxygenase-1 plays a critical anti-inflammatory role and …

Spinal cord injury (SCI) is one of the most devastating central lesions, and mitochondrial
function plays an important role in secondary injury after SCI. Polydatin (PD) is a natural …