An extended culture system that supports human primordial germ cell-like cell survival and initiation of DNA methylation erasure
The development of an in vitro system in which human primordial germ cell-like cells
(hPGCLCs) are generated from human pluripotent stem cells (hPSCs) has been invaluable …
(hPGCLCs) are generated from human pluripotent stem cells (hPSCs) has been invaluable …
Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate
SV Jostes, M Fellermeyer, L Arévalo… - … journal of cancer, 2020 - Wiley Online Library
Embryonal carcinomas (ECs) and seminomas are testicular germ cell tumors. ECs display
expression of SOX2, while seminomas display expression of SOX17. In somatic …
expression of SOX2, while seminomas display expression of SOX17. In somatic …
[HTML][HTML] Testing the role of SOX15 in human primordial germ cell fate
MP Smela, A Sybirna, FCK Wong… - Wellcome open …, 2019 - ncbi.nlm.nih.gov
Background: Potentially novel regulators of early human germline development have been
identified recently, including SOX15 and SOX17, both of which show specific expression in …
identified recently, including SOX15 and SOX17, both of which show specific expression in …
Germline development in rat revealed by visualization and deletion of Prdm14
Primordial germ cells (PGCs), the founder cells of the germline, are specified in pre-
gastrulating embryos in mammals, and subsequently migrate towards gonads to mature into …
gastrulating embryos in mammals, and subsequently migrate towards gonads to mature into …