Retinoic acid (RA) signalling has a central role during vertebrate development. RA
synthesized in specific locations regulates transcription by interacting with nuclear RA …

Retinoic acid, a derivative of vitamin A, is an essential component of cell-cell signaling
during vertebrate organogenesis. In early development, retinoic acid organizes the trunk by …

During limb development, digits emerge from the undifferentiated mesenchymal tissue that
constitutes the limb bud. It has been proposed that this process is controlled by a self …

The requirement for vitamin A in reproduction was first recognized in the early 1900's, and its
importance in the eyes of developing embryos was realized shortly after. A greater …

The limb bud is of paradigmatic value to understanding vertebrate organogenesis. Recent
genetic analysis in mice has revealed the existence of a largely self-regulatory limb bud …

Vertebrate body axis extension involves progressive generation and subsequent
differentiation of new cells derived from a caudal stem zone; however, molecular …

To determine the role of fibroblast growth factor (FGF) signalling from the apical ectodermal
ridge (AER), we inactivated Fgf4 and Fgf8 in AER cells or their precursors at different stages …

Human skeletal stem cells (SSCs) have been discovered in fetal and adult long bones.
However, the spatiotemporal ontogeny of human embryonic SSCs during early …

Limb development has long served as a model system for coordinated spatial patterning of
progenitor cells. Here, we identify a population of naive limb progenitors and show that they …

Half a century ago, the apical ectodermal ridge (AER) at the distal tip of the tetrapod limb
bud was shown to produce signals necessary for development along the proximal–distal (P …