Tubulins are essential proteins, which are conserved across all eukaryotic species. They
polymerize to form microtubules, cytoskeletal components of paramount importance for …

Stabilization of microtubule plus end-directed kinesin CENP-E at the metaphase
kinetochores is important for chromosome alignment, but its mechanism remains unclear …

Eukaryotic chromosome segregation requires kinetochores, multi-megadalton protein
machines that assemble on the centromeres of chromosomes and mediate attachments to …

Cellular machineries that drive and regulate gene expression often rely on the coordinated
assembly and interaction of a multitude of proteins and RNA together called …

The tubulin code hypothesis predicts that tubulin tails create programs for selective
regulation of microtubule-binding proteins, including kinesin motors. However, the molecular …

For accurate mitosis, all chromosomes must achieve “biorientation,” with replicated sister
chromatids coupled via kinetochores to the plus ends of opposing microtubules. However …

Fungal genetic systems ideally combine molecular tools for genome manipulation and a
sexual reproduction system to create an informative assortment of combinations of genomic …

The budding yeast Saccharomyces cerevisiae has a closed mitosis in which the mitotic
spindle and the cytoplasmic microtubules (MTs), both of which generate forces to faithfully …

Eukaryotic chromosome segregation requires kinetochores, multi-megadalton protein
machines that assemble on the centromeres of chromosomes and mediate attachments to …

Faithful segregation of chromosomes into daughter cells during mitosis requires formation of
attachments between kinetochores and mitotic spindle microtubules. Chromosome …