Ketogenic diet and epilepsy: what we know so far

I D'Andrea Meira, TT Romão… - Frontiers in …, 2019 - frontiersin.org
The Ketogenic Diet (KD) is a modality of treatment used since the 1920s as a treatment for
intractable epilepsy. It has been proposed as a dietary treatment that would produce similar …

Plant-derived antioxidants protect the nervous system from aging by inhibiting oxidative stress

X Cui, Q Lin, Y Liang - Frontiers in aging neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) has become a major disease contributing to human death and is
thought to be closely related to the aging process. The rich antioxidant substances in plants …

Diet-derived fatty acids, brain inflammation, and mental health

HM Melo, LE Santos, ST Ferreira - Frontiers in neuroscience, 2019 - frontiersin.org
Western societies experienced drastic changes in eating habits during the past century. The
modern nutritional profile, typically rich in saturated fats and refined sugars, is recognized as …

Effects of transcranial direct current stimulation paired with cognitive training on functional connectivity of the working memory network in older adults

NR Nissim, A O'Shea, A Indahlastari… - Frontiers in aging …, 2019 - frontiersin.org
Background Working memory, a fundamental short-term cognitive process, is known to
decline with advanced age even in healthy older adults. Normal age-related declines in …

Age-related alterations in DTI metrics in the human brain—consequences for age correction

A Behler, J Kassubek, HP Müller - Frontiers in aging neuroscience, 2021 - frontiersin.org
Background: Over the life span, the diffusion metrics in brain MRI show different, partly
nonlinear changes. These age-dependent changes also seem to exhibit regional …

Ketone administration for seizure disorders: history and rationale for ketone esters and metabolic alternatives

AM Poff, JM Rho, DP D'Agostino - Frontiers in Neuroscience, 2019 - frontiersin.org
The ketogenic diet (KD) is a high-fat, low-carbohydrate treatment for medically intractable
epilepsy. One of the hallmark features of the KD is the production of ketone bodies which …

Clinical features and imaging findings of myelin oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD)

Y Li, X Liu, J Wang, C Pan, Z Tang - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Myelin oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD) is a nervous system
(NS) demyelination disease and a newly recognized distinct disease complicated with …

Clinically precedented protein kinases: Rationale for their use in neurodegenerative disease

CL Benn, LA Dawson - Frontiers in Aging Neuroscience, 2020 - frontiersin.org
Kinases are an intensively studied drug target class in current pharmacological research as
evidenced by the large number of kinase inhibitors being assessed in clinical trials. Kinase …

Glycolysis-derived compounds from astrocytes that modulate synaptic communication

CA Gonçalves, L Rodrigues, LD Bobermin… - Frontiers in …, 2019 - frontiersin.org
Based on the concept of the tripartite synapse, we have reviewed the role of glucose-derived
compounds in glycolytic pathways in astroglial cells. Glucose provides energy and substrate …

Modulation of microglial activity by Rho-kinase (ROCK) inhibition as therapeutic strategy in Parkinson's disease and amyotrophic lateral sclerosis

AE Roser, L Tönges, P Lingor - Frontiers in aging neuroscience, 2017 - frontiersin.org
Neurodegenerative diseases are characterized by the progressive degeneration of neurons
in the central and peripheral nervous system (CNS, PNS), resulting in a reduced innervation …