The α‐and β‐myosin genes extend over 51 kb on chromosome 14 in human and 11 in
mouse separated by about 4.5 kb of intergenic sequence. They are located in tandem in the …

Objectives. We investigated the effect of short-and long-term swimming exercise, with or
without insulin-like growth factor (IGF)-I administration, on the expression of myocardial IGFs …

Studies have shown that protein synthesis in skeletal muscle of neonatal pigs is uniquely
sensitive to a physiological rise in both insulin and amino acids. Protein synthesis in cardiac …

Background—Release of growth hormone (GH), putatively through alterations in insulin
growth factor-1 (IGF-1) levels, has been implicated to influence left ventricular (LV) …

Owing to the role of insulin-like growth factor 1 (IGF-I) in cardiac hypertrophy and the ability
of Klotho in inhibiting the IGF-I action, we investigated effects of exercise on plasma Klotho …

GH (growth hormone) administration during acute MI (myocardial infarction) ameliorates
subsequent LV (left ventricular) dysfunction. In the present study, we examined the effects of …

We tested the hypothesis that supplemental regulatory factors can improve the contractile
properties and viability of cardiac tissue constructs cultured in vitro. Neonatal rat heart cells …

IGF-I acutely stimulates protein synthesis in cardiac muscle through acceleration of mRNA
translation. In the present study, we examined the regulatory signaling pathways and …

Background: The purpose of the present study was to determine whether acute alcohol
(EtOH) intoxication impairs the signal transduction pathway used to coordinate insulin‐like …

OBJECTIVE: Ventricular remodeling is a common corollary of myocardial infarction. We
hypothesized that this process may be attenuated by growth hormone, administered as a …